“You see all those brown little things?” Ann McKee asked me as I looked through a microscope. I was viewing a slide sample of the brain of Dave Duerson, the Notre Dame All-American defensive back who won Super Bowls with the 1985 Chicago Bears and the 1990 New York Giants. Duerson was a Notre Dame trustee, a National Football League Man of the Year for community service and an economics major who completed a management program at Harvard Business School. Early in his football retirement, he nearly tripled the annual sales of a meat supply company to $63.5 million.