Patriots quarterback Tom Brady is 13-4 in Monday night games. His best statistical performance on Monday Night Football was in the 2011 season opener at Miami, when he threw for 517 yards and four touchdowns, including a 99-yard touchdown pass to Wes Welker. Brady has thrown three or more touchdowns in a Monday Night game nine times, including four four-touchdown performances. A look at his history on Monday night:
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| Date | Opponent | Att-Com | Yards | TDs | INT | Result |
| Sept. 9, 2002 | vs. Pittsburgh | 29-43 | 294 | 3 | 0 | W, 30-14 |
| Dec. 16, 2002 | at Tennessee | 14-29 | 134 | 0 | 1 | L, 24-7 |
| Nov. 3, 2003 | at Denver | 20-35 | 350 | 3 | 1 | W, 30-26 |
| Nov. 22, 2004 | at Kansas City | 17-26 | 315 | 1 | 0 | W, 27-19 |
| Dec. 20, 2004 | at Miami | 18-29 | 171 | 3 | 4 | L, 29-28 |
| Nov. 7, 2005 | vs. Indianapolis | 22-33 | 265 | 3 | 0 | L, 41-20 |
| Dec. 26, 2005 | at NY Jets | 18-29 | 185 | 2 | 1 | W, 31-21 |
| Oct. 30, 2006 | at Minnesota | 29-43 | 372 | 4 | 1 | W, 31-7 |
| Oct. 1, 2007 | at Cincinnati | 25-32 | 231 | 3 | 1 | W, 34-13 |
| Dec. 3, 2007 | at Baltimore | 18-38 | 257 | 2 | 1 | W, 27-24 |
| Sept. 14, 2009 | vs. Buffalo | 39-53 | 378 | 2 | 1 | W, 25-24 |
| Nov. 30, 2009 | at New Orleans | 21-36 | 237 | 0 | 2 | L, 38-17 |
| Oct. 4, 2010 | at Miami | 19-24 | 153 | 1 | 0 | W, 41-14 |
| Dec. 6, 2010 | vs. NY Jets | 21-29 | 326 | 4 | 0 | W, 45-3 |
| Sept. 12, 2011 | at Miami | 32-48 | 517 | 4 | 1 | W, 38-24 |
| Nov. 21, 2011 | vs. Kansas City | 15-27 | 234 | 2 | 0 | W, 34-3 |
| Dec. 10, 2012 | vs. Houston | 21-35 | 296 | 4 | 0 | W, 42-14 |
| Totals | 378-589 | 4,715 | 41 | 14 | 13-4 |
