The new cost of hope

The families of thousands of children who want Spinraza, a newly approved drug for spinal muscular atrophy, have faced hurdles ranging from slow ramp-ups at hospitals to resistance by health insurers spooked by the $750,000 list price for the first year.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/10/17/BostonGlobe.com/Metro/Images/turner101717BIZXXspinrazaday2main44.jpg At a UMass lab, a eureka moment

This creation story began in a lab at the University of Massachusetts Medical School in Worcester.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/11/20/BostonGlobe.com/Business/Images/11-20-2017_sickelcell_02.jpg No miracle cure for rising drug costs

Conflicting interests in the health care industry make it difficult to reach a consensus on what to do.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/11/16/BostonGlobe.com/Business/Images/mehmud_4.jpg ‘Five mils of this stuff is $125,000’

A neurologist and his patient coordinator scramble to launch a Spinraza program at Johns Hopkins where 80 patients remain on a waiting list.

President Trump walked towards Marine One as he departed from the South Lawn of the White House on Saturday.

Susan Walsh/Associated Press

analysis

Trump’s greatest mission: erasing Obama’s legacy

Some attempts have failed, but the intensity of the president’s anti-Obama movement has never ebbed.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/16/BostonGlobe.com/National/Images/Rex_President_Trump_departs_for_Camp_9295054O.jpg Trump defends tax plan, proclaims economy set ‘to rock’

President Trump on Saturday defended the Republican tax cut as a good deal for the middle class.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/16/BostonGlobe.com/National/Images/13e36bf9-5050-49cc-bf39-f57bb7353664.jpg Senator Gillibrand’s star shines as nation unites behind her cause

Gillibrand has assumed her place at the head table of the Democrats’ anti-Trump movement. The reason is simple.

The Sleuths

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/11/BostonGlobe.com/Magazine/Images/teens1217boty.jpg Teen activists uncover forgotten TD Garden fund-raiser promise

Once upon a time, TD Garden’s owners promised to host three fund-raisers for the community. Everyone forgot about it until six teens from Hyde Square Task Force started digging.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/16/BostonGlobe.com/Metro/Images/StormTotalSnowWeb1.jpg Light snow expected Saturday in Western Mass. and Sunday night in Boston area

Areas in Central and Western Massahusetts may see a dusting of snow today. About an inch of snow is expected in the Boston area Sunday night into Monday morning.

Audience members at the city’s dialogue on race listened to a speaker.

Spotlight series a topic in city’s second major dialogue on race

Mayor Marty Walsh fielded questions on racial disparity, the Globe’s series on racism, and school start times, among other topics.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/16/BostonGlobe.com/Sports/Images/Ceglarski%201%20(1).jpg Former BC hockey coach Len Ceglarski dead at 91

An Olympic silver medalist and member of BC’s 1949 national championship team, Ceglarski coached the Eagles to 419 victories.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/16/BostonGlobe.com/Metro/Images/unnamed%20(7).jpg Woman rescued from icy pond in Groveland

The woman crashed a car into Johnsons Pond Saturday and was pulled from the water by police, officials said.

Person shot at Brighton housing complex

Boston police responded at 45 Faneuil St. at 5:30 p.m. for a report of a shooting, a department spokeswoman said.

Starts & Stops

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/15/BostonGlobe.com/Metro/Images/16baker01.jpg T celebrates progress — even if passengers don’t feel it

Can the T really claim to be a turnaround if riders still find the system unreliable?

Chunky Pig, a seed producer, held a Girl Scout cookie plant at the Harvest Cup on Saturday.

Pot growers, enthusiasts gather in Worcester for first-ever Harvest Cup

The event was a chance for marijuana fans and businesspeople to mingle before their world bursts into the mainstream next summer.

CELTICS 102, GRIZZLIES 93

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/17/BostonGlobe.com/Sports/Images/64a2903671ec4036aeee21bbaec177df-64a2903671ec4036aeee21bbaec177df-0.jpg Celtics rebound by repelling Grizzlies

Boston reestablished control in the fourth quarter after squandering a big early lead.

Rangers 3, Bruins 2 (OT)

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/17/BostonGlobe.com/Sports/Images/Chin121617Bruins-Rangers_Spt5.jpg Bruins bounce back, then bounced in OT by Rangers

After Boston erased a 2-0 deficit, Mats Zuccarello scored a power-play goal in overtime.

TARA SULLIVAN

/rf/image_90x90/Boston/2011-2020/2017/12/15/BostonGlobe.com/Sports/Images/Tara_Sullivan-14874.tif An ode to Brady vs. Roethlisberger

This Patriots-Steelers matchup is a reason to stop and appreciate how long and how well each has played QB for his franchise.

A better Boston? The choice is ours





It’s been more than 40 years since our national image on race was defined by the school busing crisis — years of halting progress, steps forward and back. It is high time to break that pattern.



//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/13/BostonGlobe.com/Metro/Images/kreiter_kenyattasavage4_splt.jpg The story of the only black man in a photo at a Red Sox game

Kenyatta Savage found himself featured on the front page of the Boston Globe as part of a story about racism in Boston.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/WebGraphics/Sports/BostonGlobe.com/2016/01/20moresports/seasonticket_90.jpg The Season Ticket podcast

Guest host Chad Finn chats with NFL analyst and former Pittsburgh Steelers head coach Bill Cowher.

Follow:   iTunes   |   Stitcher   |   RSS

 

Opinion & Ideas

EDITORIAL

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/13/BostonGlobe.com/Lifestyle/Images/AFP_V536Z.jpg Resources for victims of sexual misconduct

Victims of sexual misconduct are sometimes at a loss about where to turn for help — and that can hurt at a time when they most need aid or advice.

Newsletters

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/05/BostonGlobe.com/EditorialOpinion/Images/MichaelCohenNewsletterHP-3632.jpg Truth and Consequences

Opinion columnist Michael Cohen takes a candid and no-holds-barred look at the current political moment. Sign up now.

Special reports

Magazine | A nonfiction novella

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/11/01/BostonGlobe.com/Magazine/Images/muck1105altimage-2940[1].jpg He put BSO on the map — then landed in a world of trouble

One hundred years ago, one of the world’s top conductors was ensnared in a scandal involving patriotism and sex. It almost toppled Boston’s famed orchestra.

Breaking News Alerts

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Get the latest news — from weather to Trump to local happenings — delivered via Facebook messenger.

Confidential tips

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/05/22/BostonGlobe.com/Business/Images/spotlight.jpg Have an investigative news tip?

Do you know about wrongdoing that needs to be exposed? Call the Globe Spotlight team: 617-929-7483 or spotlight@globe.com.

STAT

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/15/BostonGlobe.com/National/Images/metoo%20biomedical%20science.jpg In wake of #MeToo, a new spotlight on harassment in biomedical science

Dr. Reshma Jagsi published a survey last year on harassment in the lab, and has found her research has gotten a second life.