The new cost of hope

The families of thousands of children who want Spinraza, a newly approved drug for spinal muscular atrophy, have faced hurdles ranging from slow ramp-ups at hospitals to resistance by health insurers spooked by the $750,000 list price for the first year.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/10/17/BostonGlobe.com/Metro/Images/turner101717BIZXXspinrazaday2main44.jpg At a UMass lab, a eureka moment

This creation story began in a lab at the University of Massachusetts Medical School in Worcester.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/11/20/BostonGlobe.com/Business/Images/11-20-2017_sickelcell_02.jpg No miracle cure for rising drug costs

Conflicting interests in the health care industry make it difficult to reach a consensus on what to do.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/11/16/BostonGlobe.com/Business/Images/mehmud_4.jpg ‘Five mils of this stuff is $125,000’

A neurologist and his patient coordinator scramble to launch a Spinraza program at Johns Hopkins where 80 patients remain on a waiting list.

President Trump walked towards Marine One as he departed from the South Lawn of the White House on Saturday.

Susan Walsh/Associated Press

analysis

Trump’s greatest mission: erasing Obama’s legacy

Some attempts have failed, but the intensity of the president’s anti-Obama movement has never ebbed.

More than 200 people were on hand for the funeral of Natalino Gomes this month.

Dreams of peace, family felled by gunfire

Despite efforts to get him out of Bowdoin-Geneva, Natalino Gomes could not leave his neighborhood.

Patriots at Steelers | 4:25 p.m. (CBS)

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/06/BostonGlobe.com/Sports/Images/wiggs_PatriotsPractice_05.jpg Chris Hogan reportedly to miss Patriots-Steelers game

The Patriots receiver has been battling a shoulder injury since October.

TARA SULLIVAN

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/04/BostonGlobe.com/Sports/Images/tara_sullivan_20171204.jpg An ode to Brady vs. Roethlisberger

This Patriots-Steelers matchup is a reason to stop and appreciate how long and how well each has played QB for his franchise.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/17/BostonGlobe.com/Arts/Images/200_trump_snl.jpg It was a Merry Christmas in the Oval Office on ‘Saturday Night Live’

Scarlett Johansson reprised her portrayal of Ivanka Trump, and Alec Baldwin again played the president.

Critical moment



Boston. Racism. Image. Reality.

Audience members at the city’s dialogue on race listened to a speaker.

Spotlight series a topic in city’s second major dialogue on race

Mayor Marty Walsh fielded questions on racial disparity, the Globe’s series on racism, and school start times, among other topics.

Part seven: Solutions

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/16/BostonGlobe.com/Metro/Images/Clipboard-11642.jpg A better Boston? The choice is ours

There have been years of halting progress, steps forward and back. It is high time to break that pattern.

NICK CAFARDO | SUNDAY BASEBALL NOTES

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/16/BostonGlobe.com/Sports/Images/843877108.jpg Manny Machado should be the Red Sox’ primary target

He’s the game changer Boston’s lineup needs — though he’s likely headed for a record-setting contract.

DANTE RAMOS

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/15/BostonGlobe.com/EditorialOpinion/Images/dante-3753-khvB--90x90@BostonGlobe.com.jpeg In Allston, the transit lesson we never learn

It was bad enough the first time Boston built a whole new neighborhood and forgot about transit.

Rise in HIV among drug users increases fears of new epidemic

Health officials are worried that young people, unschooled in safe injection practices, could spark an outbreak.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/17/BostonGlobe.com/Politics/Images/e6ab80fe9194498199b67478755dd8d0-e6ab80fe9194498199b67478755dd8d0-0.jpg Treasury chief can’t rule out government shutdown, but expects deal

Treasury Secretary Steven Mnuchin said he expects that lawmakers will reach bipartisan agreement on another short-term funding extension to avoid a shutdown.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/17/BostonGlobe.com/Metro/Images/StormTotalSnowWeb1-11630.jpg Clear skies expected on Sunday and a chance of snow Monday

Forecasters said the Boston area might see up to about an inch of snow Monday, but that’s not certain.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/17/BostonGlobe.com/Politics/Images/6f9a6552-4309-4e6f-898f-d7075593e301.jpg Mueller unlawfully obtained emails, Trump transition team says

An organization that was part of President Trump’s transition team claimed Saturday that special counsel Robert Mueller III improperly obtained a trove of transition emails.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/17/BostonGlobe.com/Politics/Images/0fc9159418e14366980bf2651133f4f9-615162a024d34116a70e6256f302ab37-0.jpg Kremlin says Putin thanked Trump for CIA tip on bombings

Russian President Vladimir Putin called President Trump Sunday to thank him for a CIA tip that helped thwart a series of bombings in St. Petersburg, the Kremlin said.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/17/BostonGlobe.com/Metro/Images/25437519_10215342327734904_659867753_n.jpg Mom angry after teen suspended for taking Scout knife to school

Ife Oshun says Milton’s middle school was “overstepping its boundaries. . . . He didn’t do anything wrong.”

Bostonian of the Year

The Resisters

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/11/BostonGlobe.com/Magazine/Images/main1217resisters-3335.jpg Women’s marchers and immigration attorneys take action

They battled against discrimination and for the American values they hold dear.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/16/BostonGlobe.com/Metro/Images/unnamed%20(7).jpg Woman rescued from icy pond in Groveland

The woman crashed a car into Johnsons Pond Saturday and was pulled from the water by police, officials said.

Lowell, MA: 12-05-17: Caitlyn Aguilar is pictured at her job at the Jeanne D'Arc Credit Union with her baby son Hendrix beside her. (Jim Davis/Globe Staff)

Jim Davis/Globe Staff

Baby in workplace welcomed with open arms

Caitlyn Aguiar and her 3-month-old son are the first to participate in a Lowell credit union’s Infant at Work program.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/17/BostonGlobe.com/National/Images/DEFENSE_UFO_PROGRAM_5.JPG Are UFOs real? The Pentagon tried to find out

A secret program run by the Defense Department was hidden by its miniscule budget.

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/WebGraphics/Sports/BostonGlobe.com/2016/01/20moresports/seasonticket_90.jpg The Season Ticket podcast

Guest host Chad Finn chats with NFL analyst and former Pittsburgh Steelers head coach Bill Cowher.

Follow:   iTunes   |   Stitcher   |   RSS

 

Opinion & Ideas

Ideas | Sharon Begley

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/14/BostonGlobe.com/Ideas/Images/AP_132860394523.jpg Does mental illness show up in tweets?

The flaws of in-person exams are no surprise to experts.

Newsletters

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/05/BostonGlobe.com/EditorialOpinion/Images/MichaelCohenNewsletterHP-3632.jpg Truth and Consequences

Opinion columnist Michael Cohen takes a candid and no-holds-barred look at the current political moment. Sign up now.

Special reports

Magazine | A nonfiction novella

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/11/01/BostonGlobe.com/Magazine/Images/muck1105altimage-2940[1].jpg He put BSO on the map — then landed in a world of trouble

One hundred years ago, one of the world’s top conductors was ensnared in a scandal involving patriotism and sex. It almost toppled Boston’s famed orchestra.

Breaking News Alerts

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/10/10/BostonGlobe.com/Lifestyle/Images/DKu5zGDUEAI5bSf.jpg Sign up for breaking news alerts from the Globe

Get the latest news — from weather to Trump to local happenings — delivered via Facebook messenger.

Confidential tips

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/05/22/BostonGlobe.com/Business/Images/spotlight.jpg Have an investigative news tip?

Do you know about wrongdoing that needs to be exposed? Call the Globe Spotlight team: 617-929-7483 or spotlight@globe.com.

STAT

//c.o0bg.com/rf/image_90x90/Boston/2011-2020/2017/12/15/BostonGlobe.com/National/Images/metoo%20biomedical%20science.jpg In wake of #MeToo, a new spotlight on harassment in biomedical science

Dr. Reshma Jagsi published a survey last year on harassment in the lab, and has found her research has gotten a second life.