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Momenta tops annual Globe 100 rankings

Sujatha Kumar handled test tube at Momenta in Cambridge.

Yoon S. Byun/Globe Staff

Sujatha Kumar handled a test tube at Momenta in Cambridge.

The recovery is real. Just check the 24th annual Globe 100, The Boston Globe’s ranking of the best-performing Massachusetts public companies, for the evidence.

After two years in which fewer than 100 eligible companies recorded two successive years of profits -- a Globe 100 requirement -- this year’s list, to be published online and in a special magazine on Sunday -- features a full 100 companies from industries that include life sciences, manufacturing, services, and technology, each having broken the grip of the economic downturn.

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At the top of the rankings: A generic drug company, a maker of specialty lasers, and a group of companies that manufacture parts that make industries move.

Momenta Pharmaceuticals Inc. of Cambridge, with a 383 percent rise in profits and a 142 percent increase in revenues to $179 million in 2011, ranked number one on this year’s Globe 100. The company produces the generic version of the anti-blood-clotting drug Lovenex, which has accounted for $1.5 billion in sales since it was approved by the US Food and Drug Administration in 2010.

Second was fiber laser maker IPG Photonics Corp. in Oxford; third, Altra Holdings Inc., an owner of 20 manufacturing companies that is based in Braintree; fourth, Boston digital marketing agency Sapient Corp.; and fifth, Parametric Technology Corp., or PTC, the veteran pioneer of computer-aided design software in Needham.

For the second year, the Globe 100 magazine and online package will also honor The Most Innovative in Massachusetts -- 12 inspiring individuals who did the most to boost the state’s economy and increase quality of life in the past year.

Three of our innovators exemplify the spirit and creativity that make Massachusetts a center of innovation:

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After her nephew was killed in a 2010 shooting, bank executive Monalisa Smith mobilized the community to prevent future violence. Her group, Mothers for Justice and Equality, helped to pass new legislation restricting the sale of knives to minors, created a mentoring program, and enlisted the support of state leaders right up to Gov. Deval Patrick.

Innovation consultant Matt Coates is the go-to guy for the next big thing. He teaches companies to be creative, and is the force behind such inventions as a touchscreen without fingerprints, a new design for heart valves, a method for extracting heavy oil reserves, and a product for make breath fresher.

Donato Tramuto formed a nonprofit dedicated to bringing smartphone technology to heath care givers in the most remote corners of the world. His Health eVillages has revolutionized diagnosis and communications in Haiti, China, and rural Louisiana, among other places.

The 24th annual Globe 100 will be published in full - including the top 100 comany rankins and top 12 innovators - on Sunday, May 20, in The Sunday Boston Globe and at BostonGlobe.com/Globe100.

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