Amazon.com Inc. has leased space at a prominent office building in Kendall Square where it will open a large engineering center near other major tech players that have established beachheads in Massachusetts.

The online retailing giant is leasing 105,000 square feet on several floors at 101 Main St., at the foot of the Longfellow Bridge, according to a person briefed on the deal. The company has already posted more than 30 local openings for software engineers and other tech professionals, another clear signal Amazon is speeding up efforts to establish a large presence in Massachusetts’ technology community.