A 58-year-old Roxbury man who died in a car crash near the entrance of the O’Neill Tunnel in Boston Sunday morning apparently was driving in the wrong direction, a Suffolk district attorney’s spokeswoman said.

Authorities said Idefonso Barros died in the second fatal wrong-way crash in Massachusetts of the weekend.

Police are continuing to investigate the cause of Sunday’s three-car crash, which occurred at 5:35 a.m. on Interstate 93 North, State Police said.

Barros drove a 1999 Dodge Dakota the wrong way down the I-93 Frontage Road exit toward the tunnel's entrance and crashed into a 2006 Nissan Pathfinder, said Renee Nadeau Algarin, deputy press secretary for the Suffolk district attorney’s office.

“The Nissan spun out of control and struck the left side barrier,” she said.

Firefighters extricated the Nissan driver, Jennifer Green, 45, of Chelmsford, from her sport utility vehicle. Green was taken to Tufts Medical Center and was expected to survive, State Police said.

The third driver involved in the accident, in a 2007 Ford Edge, was not injured, State Police spokesman David Procopio said.

State Police received at least one call reporting a wrong-way driver before the crash occurred, said Nadeau Algarin.

Barros was either ejected from his car or was helped out by passing drivers, State Police said. He was taken to Tufts Medical Center, where he was pronounced dead.

It appeared that all drivers were wearing seat belts, and there was no indication that drugs or alcohol were factors, Nadeau Algarin said.

On Friday night, a head-on crash involving a wrong-way driver claimed the lives of two drivers.

Clarence Lux, 84, of New Britain, Conn., drove east on the westbound lane on the Massachusetts Turnpike in Ludlow Friday and collided with Marine Corporal Robert Magee, 28, of West Bridgewater about 8:30 p.m., killing both men, police said.

“Wrong-way operator calls obviously trigger an immediate, urgent, and multiple-patrol response,” Procopio said in an e-mail.

“Troopers flood the area in an attempt to find and interdict the wrong-way driver. It is an extremely dangerous situation. If there is traffic on the road, wrong-way drivers are difficult to stop before they cause a crash, and the crashes they cause are often extremely serious, many times head-on collisions.”

On Friday, State Police received multiple calls reporting a driver traveling the wrong way in the Ludlow area about 20 minutes before the crash and sent two cruisers to seek him, but did not find Lux.

State Police are still investigating why Lux was on the wrong side of the road.

“We are investigating whether a medical condition affected the wrong-way operator and potentially contributed to his operating the wrong way,” he said.