State Police arrested four men and seized as much as 70 pounds of marijuana and $110,000 in possible drug proceeds following a four-month investigation in Eastern Massachusetts, the Norfolk district ­attorney said Wednesday.

William H. Newman, 32, of Canton, was arrested and charged with trafficking in marijuana and conspiracy to violate the drug law, District Attorney Michael W. Morrissey said. Newman pleaded not guilty Wednesday in Stoughton District Court, according to David Traub, a spokesman for the the district attorney.