Read as much as you want on BostonGlobe.com, anywhere and anytime, for just 99¢.

Specialized pill can cure gut infection

Uses feces to restore bacteria

Doctors have found a way to put healthy people’s feces into pills that can cure serious gut infections — a less yucky way to do ‘‘fecal transplants.’’ Canadian researchers tried this on 27 patients and cured them all after strong antibiotics failed to help.

Half a million Americans get Clostridium difficile, or C-diff, infections each year, and about 14,000 die. The germ causes nausea, cramping, and diarrhea so bad it is often disabling. A very potent and pricey antibiotic can kill C-diff but also destroys good bacteria that live in the gut, leaving it more susceptible to future infections.

Continue reading below

Recently, studies have shown that fecal transplants — giving infected people stool from a healthy donor — can restore that balance. But the transplants are given through expensive, invasive procedures like colonoscopies or throat tubes. Doctors also have tried giving the stool through enemas but the treatment doesn’t always take hold.

There even are YouTube videos on how to do a similar treatment at home via an enema. A study in a medical journal of a small number of these ‘‘do-it-yourself’’ cases suggests the approach is safe and effective.

Dr. Thomas Louie, an infectious disease specialist at the University of Calgary, devised a better way: a one-time treatment custom-made for each patient.

Donor stool, usually from a relative, is processed in the lab to take out food and extract the bacteria and clean it. It is packed into triple-coated gel capsules so they won’t dissolve until they reach the intestines.

Days before starting the treatment, patients are given an antibiotic to kill the C-diff. On the morning of the treatment, they have an enema so ‘‘the new bacteria coming in have a clean slate,’’ Louie said.

It takes 24 to 34 capsules to fit the bacteria needed for a treatment, and patients down them in one sitting.

The pills make their way to the colon and seed it with the normal variety of bacteria.

Loading comments...

You have reached the limit of 5 free articles in a month

Stay informed with unlimited access to Boston’s trusted news source.

  • High-quality journalism from the region’s largest newsroom
  • Convenient access across all of your devices
  • Today’s Headlines daily newsletter
  • Subscriber-only access to exclusive offers, events, contests, eBooks, and more
  • Less than 25¢ a week