ISLAMABAD — Missiles fired by a US drone killed at least 12 suspected militants near the Afghan border on Friday, Pakistani intelligence officials said.

Several insurgents were also wounded in the attack that destroyed a compound near Miran Shah, the main town of the North Waziristan tribal region, the two officials said. The drone fired five missiles.

The militants who were hit were believed to be fighters loyal to Hafiz Gul Bahadur, an insurgent commander whose forces frequently target US and NATO forces in neighboring Afghanistan.

A similar drone attack on Sunday killed eight of Bahadur’s fighters.

In a separate development Friday, a government official said gunmen killed 18 people in an attack on a restaurant in southwestern Pakistan.

Abdul Razzaq said two people were wounded in the restaurant attack in Turbat, a remote town in Baluchistan Province.

He said the dead and wounded were Pakistanis trying to travel with the help of smugglers to Europe through Iran. No other details were available.

US drones often target suspected Taliban and Al Qaeda hideouts in the tribal regions of Pakistan’s rugged northwest, but Friday’s missile attack near Miran Shah was the first since Islamabad reopened NATO supply lines to Afghanistan on Wednesday.

Pakistan closed the supply routes in November in retaliation for American airstrikes that killed 24 Pakistani soldiers.

Islamabad agreed to reopen its border to the coalition supplies after Washington apologized for the deaths of the Pakistani troops.

The drone attacks, however, remain a source of deep frustration and tension between the United States and Pakistan.