This week’s premier games:

New Orleans at Carolina

Time: 1 p.m. Line: Saints by 2½.

Records: Saints 0-1 (0-1 vs. spread), Panthers 0-1 (0-1 vs. spread).

Comments: Both teams are coming off mild upsets in their season openers . . . Series is tied at 17-17 . . . Saints QB Drew Brees has passed for at least 300 yards in an NFL-record eight straight games . . . His streak of 44 games with at least one TD pass is second only to Johnny Unitas (47) . . . Panthers QB Cam Newton has 10 TD passes and 6 rushing in seven games vs. NFC South foes . . . Carolina’s Steve Smith has 9 career TD catches vs. Saints . . . Player to watch: Nawlins’s Darren Sproles had 256 all-purpose yards vs. Carolina last season.

Baltimore at Philadelphia

Time: 1 p.m. Line: Eagles by 3.

Records: Ravens 1-0 (1-0 vs. spread), Eagles 1-0 (0-1 vs. spread).

Comments: Despite their proximity, this is just the fourth meeting between the franchises (1-1-1) . . . Eagles QB Michael Vick is 6-1 vs. AFC, throwing for 1,925 yards and 12 TDs . . . Ravens coach John Harbaugh (an Eagles assistant for 10 seasons) is 11-5 vs. NFC . . . Baltimore is 24-2 when Joe “Cool” Flacco posts a passer rating of at least 100 . . . Philly has two stud DEs in Jason Babin (7 sacks in last three vs. AFC) and Trent Cole (63 sacks since 2006) . . . Player to watch: Eagles WR/PR DeSean Jackson averages 45.4 yards per TD.

NY Jets at Pittsburgh

Time: 4:25 p.m., Ch. 4 Line: Steelers by 6.

Records: NY Jets 1-0 (1-0 vs. spread), Steelers 0-1 (0-1 vs. spread).

Comments: Steelers lead series, 15-4, but Jets have won 3 of last 4 . . . Steelers have won nine straight home openers (Patriots have won 10) . . . Pittsburgh QB Big Ben Roethlisberger is 44-13 at home and needs 176 yards to become second in franchise history with 27,000 passing yards (Terry Bradshaw) . . . Jets’ Jeremy Kerley last week became first player since 2000 with a TD catch and punt return for a score on Opening Day (Az-Zahir Hakim) . . . Player to watch: Jets QB Mark Sanchez passed for 403 yards and 2 TDs in two games vs. Steelers.

Detroit at San Francisco

Time: 8:20 p.m., Ch. 7 Line: 49ers by 6½.

Records: Lions 1-0 (0-1 vs. spread), 49ers 1-0 (1-0 vs. spread).

Comments: All eyes will be on the postgame handshake/backslap between coaches Jim Harbaugh and Jim Schwartz (bet it’s incident-free) . . . Detroit DE Cliff Avril is only player in the NFC with 10 sacks and 6 forced fumbles since 2011 . . . San Fran leads the series, 35-26-1 . . . Ultra-tough and underappreciated tailback Frank Gore rushed for 149 yards in 49ers’ win over Lions in 2011 . . . Detroit’s Calvin Johnson has 14 catches for 209 yards in last two vs. 49ers . . . Player to watch: 49ers WR Randy Moss has 72 catches for 1,182 yards in 9 TDs in 13 games vs. Lions.

The rest of this week’s games:

Tampa Bay at NY Giants

Time: 1 p.m. Line: NY Giants by 7½.

Records: Buccaneers 1-0 (1-0 vs. spread), NY Giants 0-1 (0-1 vs. spread).

Comments: A homecoming for former Rutgers coach Greg Schiano . . . Giants vaunted defensive ends Jason Pierre-Paul, Justin Tuck, and Osi Umenyiora failed to register a sack in Week 1 . . . Giants coach Tom Coughlin and QB Eli Manning are 3-0 vs. Buccaneers . . . Player to watch: Bucs’ Josh Freeman is one of two QBs with more than 7,000 yards passing and 600 yards rushing since 2010.

Oakland at Miami

Time: 1 p.m. Line: Raiders by 2½.

Records: Raiders 0-1 (0-1 vs. spread), Dolphins 0-1 (0-1 vs. spread).

Comments: Miami hasn’t won a home opener since 2005 and is 0-7 in September at home since 2007 . . . Sebastian Janikowski is three PATs shy of becoming Raiders all-time leader . . . QB Carson Palmer is averaging 293.4 passing yards in 10 games as a Raider . . . Player to watch: Dolphins QB Ryan Tannehill had three picks and six tipped passes last week.

Houston at Jacksonville

Time: 1 p.m. Line: Texans by 7.

Records: Texans 1-0 (1-0 vs. spread), Jaguars 0-1 (1-0 vs. spread).

Comments: A battle between league’s top rushers the last two seasons: Houston’s Arian Foster had 1,616 yards in 2010; Jacksonville’s Maurice Jones-Drew collected 1,606 in ‘11 . . . Last four in this series were decided by 6 points or less . . . Houston hopes for third straight 2-0 start . . . Player to watch: Texans WR Andre Johnson has 87 career receptions vs. Jags.

Cleveland at Cincinnati

Time: 1 p.m. Line: Bengals by 8.

Records: Browns 0-1 (1-0 vs. spread), Bengals 0-1 (0-1 vs. spread).

Comments: Believe it or not, Bungles have won 12 of last 15 in this Buckeye State battle . . . Cleveland hasn’t won an AFC North opener since 2007 . . . Cincy’s Leon Hall has five career INTs vs. Brownies . . . Cleveland forced five turnovers in last week’s loss to Philadelphia . . . Player to watch: Browns rookie QB Brandon Weeden went 12 for 35 for 118 yards and 5.1 passer rating in his debut.

Kansas City at Buffalo

Time: 1 p.m. Line: Bills by 3½.

Records: Chiefs 0-1 (0-1 vs. spread), Bills 0-1 (0-1 vs. spread).

Comments: Buffalo opened last season at 5-2 and is 1-9 since . . . Since 1995, Chiefs are 98-29 when leading at the half . . . Bills allowed 24 points off four turnovers in Week 1 . . . KC WR Dwayne Bowe is 20 yards shy of becoming eighth receiver in franchise history to reach 5,000 . . . Player to watch: Bills’ C.J. Spiller rushed for a career-high 169 yards last week.

Minnesota at Indianapolis

Time: 1 p.m. Line: Vikings by 1.

Records: Vikings 1-0 (0-1 vs. spread), Colts 0-1 (0-1 vs. spread).

Comments: Colts are 9-0 at home vs. Vikings, but have never hosted them at Lucas Oil Stadium . . . Colts’ Adam Vinatieri has scored in 131 straight games dating back to his Patriots days . . . Vikings are 79-70 all-time vs. AFC . . . Indy rook Andrew Luck passed for 309 yards last week, a franchise mark for a debut game . . . Player to watch: Vikings DE Jared Allen led league with 22 sacks in 2011.

Washington at St. Louis

Time: 4:05 p.m. Line: Redskins by 3.

Records: Redskins 1-0 (1-0 vs. spread), Rams 0-1 (1-0 vs. spread).

Comments: Since 2006, Rams RB Steven Jackson has averaged 114.4 scrimmage yards per game . . . Redskins pulled off a trade with Rams to grab Robert Griffin III with second overall pick . . . Redskins’ Brian Orakpo had 2½ sacks and a forced fumble in only game vs. Rams . . . Player to watch: Rams DE Chris Long has 10 sacks in his last 11 games and 13 in last 13 home tilts.

Dallas at Seattle

Time: 4:05 p.m. Line: Cowboys by 3.

Records: Cowboys 1-0 (1-0 vs. spread), Seahawks 0-1 (0-1 vs. spread).

Comments: Cowboys are shooting for the 450th win in franchise history . . . Seattle’s Marshawn Lynch has rushed for 1,026 yards rushing in 10 games . . . Dallas hasn’t been 2-0 since 2008 . . . Both teams were hit with a league-high 13 penalties in Week 1 . . . Player to watch: Cowboys QB Tony Romo has a 35-8 record when he records a passer rating of 100-plus.

Tennessee at San Diego

Time: 4:25 p.m. Line: Chargers by 5.

Records: Titans 0-1 (0-1 vs. spread), Chargers 1-0 (1-0 vs. spread).

Comments: Chargers will retire Junior Seau’s No. 55 in a pregame ceremony . . . San Diego has won eight straight in the series . . . Titans’ Chris Johnson last week became second RB in franchise history with 200 receptions (Eddie George) . . . Player to watch: Chargers safety Eric Weddle has a league-high seven INTs since 2011.

Denver at Atlanta

Time: Monday, 8:20 p.m., ESPN Line: Falcons by 3.

Records: Broncos 1-0 (1-0 vs. spread), Falcons 1-0 (1-0 vs. spread).

Comments: Broncos are playing a “Monday Night Football” tilt for the 21st straight year — longest active streak in NFL . . . Denver has won seven of last eight in the series . . . Falcons are 26-6 at home under coach Mike Smith . . . Atlanta’s Matt Bryant has made 17 consecutive field goal attempts, including four last week at Kansas City . . . Player to watch: Falcons DE John Abraham has 113 sacks, tops among active NFLers.