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Week 5 NFL preview

Steelers quarterback Ben Roethlisberger, who last met the Eagles during the preseason, will be seeing them again on Sunday.

Mel Evans/AP

Steelers quarterback Ben Roethlisberger, who last met the Eagles during the preseason, will be seeing them again on Sunday.

Philadelphia at Pittsburgh

Time: 1 p.m., Fox. Line: Steelers by 3½.

Records: Eagles 3-1 (0-3-1 vs. spread), Steelers 1-2 (1-2 vs. spread).

Comments: Eagles lead the much-ballyhooed Keystone State series, 46-27-3 . . . OK, it’s not that ballyhooed . . . Eagles QB Michael Vick is 14-3 in his last 17 vs. AFC . . . Pittsburgh leads NFL with 56.3 conversion rate on third down . . . Philly DE Jason Babin has 10½ sacks in last nine games . . . Pittsburgh TE Heath Miller has a TD catch in three straight . . . Steelers are 14-9 after bye since 1990 . . . Player to watch: Steelers QB Big Ben Roethlisberger is 60 of 80 for 659 yards with 6 TDs and 0 picks in his last two games.

Key injuries: EAGLES: OUT: LB Akeem Jordan (hamstring). QUESTIONABLE: S Colt Anderson (knee), T King Dunlap (hamstring), DT Derek Landri (knee). PROBABLE: WR Jason Avant (wrist), LB Jamar Chaney (knee), WR Riley Cooper (collarbone), C Jon Dorenbos (ankle), WR Damaris Johnson (foot), LB Mychal Kendricks (calf), G Danny Watkins (chest). STEELERS: PROBABLE: T Marcus Gilbert (groin), LB James Harrison (knee), RB Rashard Mendenhall (knee), S Troy Polamalu (calf).

Buffalo at San Francisco

Time: 4:25 p.m. Line: 49ers by 9½.

Records: Bills 2-2 (2-2 vs. spread), 49ers 3-1 (3-1 vs. spread).

Comments: You have been paying attention if you knew the Bills lead the NFL with 16 TDs (I thought the Patriots scored that many in Buffalo last week) . . . 49ers WR Randy Moss has 12 TDs in 10 games against Bills . . . Buffalo’s Fred Jackson has rushed for at least 111 yards in four straight vs. NFC foes . . . All-time series is tied at 5-5 . . . Bills DT Kyle Williams has 3½ sacks in last three games . . . Player to watch: San Fran QB Alex Smith has won 17 of last 21 starts and his club is 12-0 when he posts a passer rating of 100-plus.

Key injuries: BILLS: OUT: T Cordy Glenn (ankle), DE Spencer Johnson (ankle), G Kraig Urbik (ankle). QUESTIONABLE: S Jairus Byrd (hip), WR Ruvell Martin (ankle), G Chad Rinehart (calf). PROBABLE: TE Scott Chandler (head), WR Donald Jones (head). 49ERS: QUESTIONABLE: RB Brandon Jacobs (knee), CB Carlos Rogers (knee), NT Isaac Sopoaga (knee, ankle). PROBABLE: LB Navorro Bowman (shoulder), P Andy Lee (hand).

San Diego at New Orleans

Time: 8:20 p.m., NBC Line: Saints by 3½.

Records: Chargers 3-1 (3-1 vs. spread), Saints 0-4 (1-3 vs. spread).

Comments: As if being 0-4 wasn’t motivation enough, Saints’ Drew Brees gets to face off against his former team and the QB (Philip Rivers) who replaced him in 2006 . . . Since joining the Saints, Brees has passed for 29,744 yards . . . Rivers has 25,182 passing yards . . . Chargers’ Malcom Floyd is eight receptions shy of 200 . . . Saints WR Marques Colston has nine TDs in his last 10 games vs. AFC opponents . . . Player to watch: San Diego safety Eric Weddle leads the NFL since 2011 with 11 interceptions.

Key injuries: CHARGERS: OUT: K Nate Kaeding (right groin), CB Shareece Wright (foot). PROBABLE: G Tyronne Green (knee). SAINTS: OUT: RB Travaris Cadet (shoulder), LB David Hawthorne (hamstring), DE Turk McBride (ankle), WR Lance Moore (hamstring). QUESTIONABLE: LB Jonathan Casillas (neck), S Roman Harper (hip), WR Joseph Morgan (knee).

Houston at New York Jets

Time: Monday, 8:30 p.m., ESPN Line: Texans by 8½.

Records: Texans 4-0 (4-0 vs. spread), Jets 2-2 (2-2 vs. spread).

Comments: Jets are 2-2 but it sure feels like they’re 0-4 . . . Texans are 4-0 for first time in history but 0-5 all-time vs. Gang Green . . . Jets are 4-0 when Shonn Greene rushes for at least 100 yards . . . Houston’s J.J. Watt is first NFLer to have at least 1½ sacks in each of his team’s first four games since Kevin Greene in 1998 (is that enough green references for you?) . . . Texans allow AFC-low 182.8 passing yards per game . . . Player to watch: Houston QB Matt Schaub is 8-0 with 1,835 yards and 12 TDs in his last eight starts.

Key injuries: TEXANS: DNP: S Quintin Demps (thumb, forearm), WR Lestar Jean (knee), G Wade Smith (knee), RB Ben Tate (toe). LIMITED: G Antoine Caldwell (ankle, knee), NT Shaun Cody (back), TE Owen Daniels (thigh), WR Andre Johnson (groin), S Shiloh Keo (neck), DE Antonio Smith (ankle). FULL: LB Mister Alexander (hip), LB Bryan Braman (hamstring, neck), LB Tim Dobbins (hamstring), RB Arian Foster (hamstring), LB Bradie James (thigh), C Chris Myers (back), LB Jesse Nading (foot). JETS: OUT: CB Darrelle Revis (knee). DNP: RB John Conner (hamstring), WR Stephen Hill (hamstring), TE Dustin Keller (hamstring), S LaRon Landry (heel), RB Joe McKnight (illness), DT Sione Po’uha (back). LIMITED: CB Aaron Berry (ribs), LB Bart Scott (toe), S Eric Smith (hip, knee), LB Bryan Thomas (hamstring). FULL: LB Nick Bellore (shoulder), S Yeremiah Bell (shoulder), S Josh Bush (shoulder), CB Antonio Cromartie (shoulder), TE Jeff Cumberland (ribs), DE Mike DeVito (neck), T Austin Howard (back), WR Jeremy Kerley (finger), C Nick Mangold (wrist), G Brandon Moore (hip), LB Calvin Pace (Achilles), QB Mark Sanchez (back), G Matt Slauson (knee).

Miami at Cincinnati

Time: 1 p.m. Line: Bengals by 3.

Records: Dolphins 1-3 (2-2 vs. spread), Bengals 3-1 (2-1-1 vs. spread).

Comments: An Ohio homecoming for Dolphins’ Brian Hartline, who leads the NFL with 455 receiving yards . . . Bengals’ A.J. Green has at least 100 receiving yards in each of his last two games . . . Miami’s Cameron Wake collected a career-high 4½ sacks last week . . . Bengals lead NFL with 17 sacks . . . Player to watch: Cincy QB Andy Dalton leads the NFL with a 151.7 passer rating.

Key injuries: DOLPHINS: OUT: CB Richard Marshall (back). PROBABLE: LB Kevin Burnett (foot), RB Reggie Bush (hip), CB Nolan Carroll (Achilles), DT Tony McDaniel (knee), WR Marlon Moore (hamstring), DT Paul Soliai (ankle), LB Austin Spitler (groin), QB Ryan Tannehill (right thumb). BENGALS: DOUBTFUL: CB Jason Allen (quadriceps), CB Dre Kirkpatrick (knee). PROBABLE: LB Vontaze Burfict (hamstring), CB Nate Clements (calf), DE Carlos Dunlap (groin), C Jeff Faine (hamstring), CB Leon Hall (hamstring), RB Bernard Scott (ankle), LB Dan Skuta (back), T Andrew Whitworth (knee).

Green Bay at Indianapolis

Time: 1 p.m. Line: Packers by 7.

Records: Packers 2-2 (1-3 vs. spread), Colts 1-2 (1-2 vs. spread).

Comments: Bruce Arians takes over the Colts’ reins as coach Chuck Pagano undergoes treatment for leukemia . . . Packers QB Aaron Rodgers is 5-1 in his last six vs. AFC foes . . . Indy has had three different receivers eclipse 100 yards in first three games for the first time since 1967 . . . Player to watch: Colts’ Robert Mathis has registered at least one sack in six consecutive games.

Key injuries: PACKERS: OUT: WR Greg Jennings (groin), S Sean Richardson (hamstring). QUESTIONABLE: CB Davon House (shoulder). PROBABLE: S M.D. Jennings (neck), DT Ryan Pickett (shoulder, knee). COLTS: OUT: LB Pat Angerer (foot), CB Vontae Davis (ankle), CB Justin King (groin), G Seth Olsen (knee), G Joe Reitz (knee). QUESTIONABLE: TE Coby Fleener (head), LB Dwight Freeney (ankle), RB Mewelde Moore (ankle), C Samson Satele (knee). PROBABLE: LB Robert Mathis (ankle).

Baltimore at Kansas City

Time: 1 p.m. Line: Ravens by 6½.

Records: Ravens 3-1 (2-2 vs. spread), Chiefs 1-3 (1-3 vs. spread).

Comments: The Ravens have won four straight vs. the Chiefs . . . Kansas City has won six straight October games . . . Baltimore leads the NFL with 26 plays of 20 or more yards (and no, they didn’t all come against the Patriots) . . . Chiefs have won last six home games when Matt Cassel posts a 100-plus passer rating . . . Player to watch: Ravens WR Torrey Smith has 12 catches for 224 yards in his last two games.

Key injuries: RAVENS: QUESTIONABLE: T Jah Reid (calf). PROBABLE: WR Torrey Smith (ankle). CHIEFS: OUT: DE Glenn Dorsey (calf), RB Peyton Hillis (ankle), WR Devon Wylie (hamstring). DOUBTFUL: CB Jalil Brown (hamstring). QUESTIONABLE: LB Derrick Johnson (groin), S Kendrick Lewis (shoulder), DE Ropati Pitoitua (elbow). PROBABLE: WR Jon Baldwin (hamstring), CB Brandon Flowers (heel), G Ryan Lilja (back).

Tennessee at Minnesota

Time: 4:25 p.m. Line: Vikings by 5½.

Records: Titans 1-3 (1-3 vs. spread), Vikings 3-1 (2-2 vs. spread).

Comments: Matt Hasselbeck gets the call at QB for Titans with Jake Locker (dislocated nonthrowing shoulder) on the shelf . . . Since coming into the NFL in 2007, Minny’s Adrian Peterson has league-leading 7,084 rushing yards . . . Since 2011, Titan Jared Cook has 957 yards (only Rob Gronkowski and Aaron Hernandez have more among TEs) . . . Player to watch: Vikings’ Christian Ponder is the only starting QB with zero interceptions (123 passes).

Key injuries: TITANS: OUT: QB Jake Locker (left shoulder). QUESTIONABLE: LB Patrick Bailey (hand), WR Kenny Britt (ankle), LB Colin McCarthy (ankle), T Mike Otto (finger), DE Scott Solomon (hamstring). PROBABLE: TE Jared Cook (shoulder). VIKINGS: OUT: S Mistral Raymond (ankle), S Andrew Sendejo (ankle). DOUBTFUL: LB Marvin Mitchell (calf). QUESTIONABLE: LB Erin Henderson (concussion), WR Michael Jenkins (rib). PROBABLE: DE Jared Allen (groin), G Charlie Johnson (low back), QB Christian Ponder (knee), CB Marcus Sherels (quadriceps), CB Antoine Winfield (knee).

Cleveland at New York Giants

Time: 1 p.m., CBS Line: Giants by 8½.

Records: Browns 0-4 (2-1-1 vs. spread), Giants 2-2 (1-2-1 vs. spread).

Comments: Giants QB Eli Manning has won seven straight games vs. the AFC and has passed for at least 200 yards in 23 consecutive games . . . Browns QB Brandon Weeden has posted back-to-back 300-yard efforts . . . Cleveland is tied for tops in AFC with six interceptions . . . Giants FB Henry Hynoski’s father, Henry Sr., played for Browns in 1975 . . . Player to watch: Browns rookie Trent Richardson has a rushing TD in three straight games.

Key injuries: BROWNS: OUT: S Tashaun Gipson (knee), TE Alex Smith (head). DOUBTFUL: WR Travis Benjamin (hamstring), WR Mohamed Massaquoi (hamstring). QUESTIONABLE: S T.J. Ward (hand). PROBABLE: WR Joshua Cribbs (head), RB Trent Richardson (not injury related), DE Frostee Rucker (shoulder), S Ray Ventrone (hand, calf), S Usama Young (knee). GIANTS: OUT: WR Ramses Barden (concussion), DT Rocky Bernard (quadriceps), CB Jayron Hosley (hamstring), WR Hakeem Nicks (foot, knee), S Kenny Phillips (knee). DOUBTFUL: T David Diehl (knee), LB Keith Rivers (hamstring). QUESTIONABLE: LB Michael Boley (hip), S Antrel Rolle (knee), G Chris Snee (hip), CB Corey Webster (hand, hamstring). PROBABLE: C David Baas (hand), CB Michael Coe (hamstring).

Atlanta at Washington

Time: 1 p.m. Line: Falcons by 3.

Records: Falcons 4-0 (3-1 vs. spread), Redskins 2-2 (2-2 vs. spread).

Comments: Falcons’ Matty “Ice’’ Ryan leads the NFL with a 112.1 passer rating . . . Redskins’ Robert Griffin III leads NFL rookies with 103.2 passer rating (fourth overall) . . . Washington’s Santana Moss has 12 catches for 170 yards in two games vs. Atlanta . . . Falcons are least-penalized team (114 yards) while Redskins are most-penalized (356) . . . Player to watch: Washington’s Alfred Morris leads NFL rookies with 376 rushing yards.

Key injuries: FALCONS: OUT: TE Michael Palmer (shoulder). QUESTIONABLE: C Todd McClure (pectoral), S William Moore (hip), RB Lousaka Polite (hamstring). PROBABLE: DT Jonathan Babineaux (groin), WR Julio Jones (hand), LB Stephen Nicholas (thigh), CB Christopher Owens (head), RB Antone Smith (hamstring). REDSKINS: OUT: CB Cedric Griffin (hamstring), S Brandon Meriweather (knee). QUESTIONABLE: RB Evan Royster (knee). PROBABLE: WR Brandon Banks (hip), WR Pierre Garcon (foot), CB DeAngelo Hall (illness), WR Aldrick Robinson (head), T Trent Williams (knee).

Seattle at Carolina

Time: 4:05 p.m. Line: Panthers by 3.

Records: Seahawks 2-2 (2-2 vs. spread), Panthers 1-3 (2-2 vs. spread).

Comments: Seahawks’ Marshawn Lynch leads the NFL with 423 rushing yards . . . Carolina’s Cam Newton’s 17 rushing TDs are most by a QB in his first two seasons . . . Seattle defense is second best in NFL against the run (62.8 yards per game) . . . Seahawks have 10 players with at least one catch . . . Player to watch: Panthers DE Charles Johnson posted a career-high 3½ sacks last week.

Key injuries: SEAHAWKS: OUT: DT Jaye Howard (foot), G John Moffitt (knee). QUESTIONABLE: CB Marcus Trufant (back). PROBABLE: RB Marshawn Lynch (rest), DT Brandon Mebane (calf). PANTHERS: OUT: G Mike Pollak (shoulder). DOUBTFUL: LB Jon Beason (knee), CB Chris Gamble (shoulder). QUESTIONABLE: C Geoff Hangartner (knee). PROBABLE: DE Frank Alexander (back), DE Antwan Applewhite (knee), S Colin Jones (shoulder).

Chicago at Jacksonville

Time: 4:05 p.m. Line: Bears by 5½.

Records: Bears 3-1 (3-1 vs. spread), Jaguars 1-3 (2-2 vs. spread).

Comments: Da Bears are 6-0 after “Monday Night Football’’ road games . . . Chicago’s Alshon Jeffery leads NFL rookies with 164 receiving yards . . . Jaguars, who are debuting new black jerseys, are 6-1 in their last seven games before the bye week . . . Bears have an NFL-high 14 takeaways . . . Both clubs feature a Brandon Marshall . . . Jacksonville’s Maurice Jones-Drew is 41 all-purpose yards shy of 12,000 for his career . . . Player to watch: Chicago DE Julius Peppers has seven sacks in his last eight vs. AFC.

Key injuries: BEARS: OUT: RB Evan Rodriguez (knee). QUESTIONABLE: WR Earl Bennett (hand). PROBABLE: RB Matt Forte (ankle), DE Julius Peppers (ankle). JAGUARS: OUT: WR Laurent Robinson (concussion), LB Daryl Smith (groin). QUESTIONABLE: DE George Selvie (knee).

Jim McBride can be reached at j_mcbride@globe.com.