Michael Dwyer/Associated press

Patriots quarterback Tom Brady crouched in a huddle before hosting the Colts.

Matthew J. Lee/Globe staff

Rob Gronkowski, who had two touchdowns, made a long reception in the first quarter.

Steven Senne/associated press

Julian Edelman, who had 222 all-purpose yards, advanced downfield Colts as safety Tom Zbikowski tried to make a tackle in the first quarter.

Steven Senne/associated press

Colts running back Delone Carter opened the scoring with a first-quarter touchdown.

Jessica Rinaldi/Reuters

Patriots receiver Wes Welker was tackled by the Colts' Jerrell Freeman during the first half.

Matthew J. Lee/Globe staff

Gronkowski was tackled by Freeman after an 18-yard reception during the second quarter.

Charles Krupa/associated press

Brady eluded Colts defensive end Ricardo Mathews to get a pass off during the second quarter.

Matthew J. Lee/Globe staff

Edelman returned this punt 68 yards for a touchdown during the second quarter.

Jim Davis/Globe Staff

Edelman high-stepped into the end zone as he celebrated the score.

Charles Krupa/associated press

It was one of two touchdowns during the game for Edelman.

Charles Krupa/associated press

Patriots head coach Bill Belichick took some time meeting with defensive players on the bench during the game.

Matthew J. Lee/Globe staff

New Patriots cornerback Aqib Talib returned a interception for a touchdown during second quarter.

Charles Krupa/associated press

Talib was congratulated by Jerod Mayo, left, and Alfonzo Dennard, right, after his score.

Jim Davis/Globe Staff

Gronkowski couldn't be stopped by Zbikowski as he headed into the end zone with a third quarter 24 yard touchdown reception.

Steven Senne/associated press

Colts defensive end Cory Redding was helped off the field in the second half.

Matthew J. Lee/Globe staff

Gronkowski was pushed out of bounds by Freeman after a 31-yard reception during third quarter.

Matthew J. Lee/Globe staff

Brady celebrated with teammate Gronkowski after their 24-yard touchdown connection during third quarter.

Jim Davis/Globe Staff

Gronkowski did his customary spike, but went on to suffer a broken left forearm late in the fourth quarter.

Matthew J. Lee/Globe staff

Patriots running back Stevan Ridley was upended by Cassius Vaughn and Antoine Bethea after an 11-yard run during the third quarter.

Matthew J. Lee/Globe staff

Colts quarterback Andrew Luck picked himself off the turf after throwing his third interception during the fourth quarter.

Steven Senne/associated press

Gronkowski, right, celebrated a touchdown with Edelman as Zbikowski walked away.

Michael Dwyer/associated press

Colts punter Pat McAfee had to tackle Edelman to prevent a potential second punt return for a touchdown.

Jim Davis/Globe Staff

Brady ended up with 331 yards passing and three touchdown tosses.

Jim Davis/Globe Staff

Patriots cornerback Alfonzo Dennard also returned an interception for a touchdown.

Matthew J. Lee/Globe staff

Patriots running back Shane Vereen capped the scoring with a 4-yard run in the fourth quarter.

Charles Krupa/associated press

Brady led the Patriots to 59 points, which tied the franchise record.

Matthew J. Lee/Globe staff

It marked the second time this season, and fifth since 2007, that the Patriots scored more than 50 points in one game.