The Red Sox have 38 games scheduled in Florida, with spring training exhibitions commencing Feb. 21 at JetBlue Park in Fort Myers.
| Date | Opponent | Site | Time |
| Thu., Feb. 21 | Northeastern | JetBlue Park | 1:35 p.m. |
| Boston College | TBA | ||
| Sat., Feb. 23 | Tampa Bay | JetBlue Park | 1:35 p.m. |
| Sun., Feb. 24 | St. Louis | Jupiter | 1:05 p.m. |
| Mon. Feb. 25 | Tampa Bay (ss) | Port Charlotte | 1:05 p.m. |
| Toronto (ss) | Dunedin | 1:05 p.m. | |
| Tue., Feb. 26 | St. Louis | JetBlue Park | 1:35 p.m. |
| Wed., Feb. 27 | Baltimore | Sarasota | 7:05 p.m. |
| Thu., Feb. 28 | Pittsburgh | Bradenton | 1:05 p.m. |
| Fri., March 1 | Pittsburgh | JetBlue Park | 7:05 p.m. |
| Sat., March 2 | Minnesota | Hammond Stadium | 1:05 p.m. |
| Sun., March 3 | NY Yankees | JetBlue Park | 1:35 p.m. |
| Mon., March 4 | Tampa Bay | JetBlue Park | 1:35 p.m. |
| Tue., March 5 | Team Puerto Rico* | JetBlue Park | 7:05 p.m. |
| Wed., March 6 | Pittsburgh | JetBlue Park | 1:35 p.m. |
| Thu., March 7 | Minnesota | Hammond Stadium | 1:05 p.m. |
| Fri., March 8 | Minnesota | JetBlue Park | 7:05 p.m. |
| Sat., March 9 | Baltimore | JetBlue Park | 7:05 p.m. |
| Sun., March 10 | Tampa Bay | Port Charlotte | 1:05 p.m. |
| Mon., March 11 | Miami | Jupiter | 1:05 p.m. |
| Tue., March 12 | Toronto | JetBlue Park | 1:35 p.m. |
| Thu., March 14 | Minnesota | Hammond Stadium | 1:05 p.m. |
| Fri., March 15 | Minnesota (ss) | JetBlue Park | 7:05 p.m. |
| Baltimore (ss) | Sarasota | 1:05 p.m. | |
| Sat., March 16 | Tampa Bay | Port Charlotte | 1:05 p.m. |
| Sun., March 17 | Tampa Bay | JetBlue Park | 1:35 p.m. |
| Mon., March 18 | Pittsburgh | Bradenton | 1:05 p.m. |
| Tue., March 19 | Baltimore | JetBlue Park | 1:35 p.m. |
| Wed., March 20 | NY Yankees | Tampa | 1:05 p.m. |
| Thu., March 21 | Philadelphia | JetBlue Park | 7:05 p.m. |
| Fri., March 22 | Toronto | Dunedin | 1:05 p.m. |
| Sat., March 23 | Pittsburgh | JetBlue Park | 1:35 p.m. |
| Sun., March 24 | Philadelphia | Clearwater | 1:05 p.m. |
| Mon., March 25 | Baltimore | Sarasota | 1:05 p.m. |
| Wed., March 27 | Miami | JetBlue Park | 1:35 p.m. |
| Thu., March 28 | Minnesota | JetBlue Park | 7:05 p.m. |
| Fri., March 29 | Minnesota | Hammond Stadium | 1:05 p.m. |
| Sat., March 30 | Minnesota | JetBlue Park | 1:35 p.m. |
ss — split squad; * — World Baseball Classic exhibition