No. 1 Alabama vs. No. 21 Mississippi
The Tide have won the last nine meetings, though three of the victories were vacated from 2005-07. The Rebels are seeking their first 4-0 start since 1970. They’re 0-9 against No. 1 teams and haven’t faced a ranked opponent this season.
No. 2 Oregon vs. California
The Ducks rank in the top five nationally in scoring offense (61.3) and scoring defense (9.0). Cal has not defeated a ranked opponent on the road since beating No. 14 Stanford in 2009 and is winless in Eugene since 2007.
No. 3 Clemson vs. Wake Forest
The Tigers are 12th in the 14-team ACC in passing defense, allowing more than 230 yards a game. Clemson has won four straight in the series and six of the past seven, with the lone loss in 2008.
No. 4 Ohio State vs. No. 23 Wisconsin
The Badgers are third in the nation in rushing, averaging 350 yards per game. The Buckeyes’ interior defense includes six first-year starters among the front seven.
No. 5 Stanford at Washington State
When these programs met last season, the Cardinal set a school record with 10 sacks and had 15 tackles for loss in the 24-17 victory. Saturday’s game is at CenturyLink Field in Seattle.
No. 6 LSU at No. 9 Georgia
The Tigers’ Jeremy Hill is coming off a career-best 184 yards rushing and three touchdowns in a victory over Auburn. The Bulldogs limited North Texas to 7 yards rushing last week. LSU has won 29 straight games in September, a streak that dates to 2006.
No. 8 Florida State at BC
BC’s Andre Williams leads the ACC with 118.7 yards rushing per game. The Seminoles are allowing 135.5 yards per game on the ground, ranking 45th in the nation. Florida State is a 21½-point favorite at Alumni Stadium.
No. 10 Texas A&M at Arkansas
Aggies QB Johnny Manziel accounted for 557 yards of total offense (453 passing, 104 rushing) in a 58-10 win over the Razorbacks a year ago. A&M leads the SEC in scoring with an average of 50.2 points per game.
No. 11 Oklahoma State at West Virginia
The Cowboys have outscored opponents, 136-41, and are looking for their third 4-0 start in four seasons. West Virginia coach Dana Holgorsen was the offensive coordinator under Mike Gundy at Oklahoma State in 2010.
No. 12 South Carolina at Central Florida
The Gamecocks are trying to extend their streak of 17 regular-season victories against nonconference opponents. The Knights are coming off a triumph at Penn State and are looking to move to 4-0 for the first time since 1988.
No. 14 Oklahoma at No. 22 Notre Dame
Oklahoma wants to avenge last season’s 30-13 loss in Norman to the Irish. The Sooners are 16-4 coming off bye weeks under coach Bob Stoops. Notre Dame is 28-4-1 against current members of the Big 12.
No. 15 Miami at South Florida
At 3-0, the Hurricanes are off to their best start since opening 6-0 in 2004. Miami’s Duke Johnson has averaged 6.3 yards per carry while rushing for 304 yards and three touchdowns. He’s also averaged nearly 38 yards per kickoff. USF has lost 12 of its last 13 games.
No. 16 Washington vs. Arizona
Both teams are 3-0 heading into their Pac-12 opener. Ka’Deem Carey, the national rushing leader in 2012, ran for 172 yards and the Wildcats rolled up 277 yards rushing against the Huskies last season. Washington is No. 3 in the country in total offense, averaging 629 yards per game.
No. 20 Florida at Kentucky
The Gators have won 26 straight in the series, unbeaten against the Wildcats since 1986. Florida’s winning streak against Kentucky is the current longest in an interrupted series between two teams. QB Tyler Murphy will make his first career start for the Gators.
No. 25 Fresno State at Hawaii
Fresno is in the AP poll for the first time since 2008. The Bulldogs are 11-0 under coach Tim DeRuyter when scoring at least 30 points.