No. 1 Alabama vs. Georgia State
Crimson Tide quarterback AJ McCarron is seeking his 30th win, which would tie him with Harry Gilmer at No. 3 on the team’s winningest quarterbacks list.
No. 2 Oregon at Colorado
With explosive running back De’Anthony Thomas unlikely to play because of a balky right ankle, Byron Marshall will have to pick up the slack for the Ducks .
No. 3 Clemson at Syracuse
The Orange defense is averaging seven three-and-outs per game, tied for third in the FBS. Tigers quarterback Tajh Boyd is just the second ACC quarterback to account for 100 career touchdowns.
No. 4 Ohio State at No. 16 Northwestern
The Buckeyes have won 17 in a row, the longest active streak in the nation. RB Venric Mark is expected back for the Wildcats after missing three games due to injury.
No. 5 Stanford vs. No. 15 Washington
The Cardinal are 9-0 under QB Kevin Hogan, who did not play in the loss to the Huskies last year. The Huskies are led by RB Bishop Sankey, who leads the nation with 151.8 yards per game.
No. 6 Georgia at Tennessee
Bulldogs QB Aaron Murray needs fewer than 100 passing yards to become the SEC’s all-time leader. He faces an inexperienced Volunteers secondary that has intercepted an FBS-leading 11 passes.
No. 7 Louisville at Temple
The Cardinals are holding opponents to 3.7 yards per play and have allowed just 10 plays of 20 or more yards in four games.
No. 8 Florida State vs. No. 25 Maryland
Terrapins QB C.J. Brown leads the ACC in total offense with 331.5 yards per game. The Seminoles must win to keep their national title hopes alive.
No. 10 LSU at Mississippi State
The Tigers are 20-1 under Les Miles after a loss. The Bulldogs are looking for their first win against LSU since 1999.
No. 11 Oklahoma vs. TCU
Sooners QB Blake Bell has not thrown an interception this season. The Horned Frogs’ defense has the longest current streak among FBS teams of holding an opponent to less than 60 percent completions.
No. 13 South Carolina vs. Kentucky
The Wildcats allow 175 yards passing. Gamecocks QB Connor Shaw should play after injuring his throwing shoulder last week.
No. 14 Miami vs. Georgia Tech
It will be incumbent upon the Hurricanes defense to be disciplined in order to stop the Yellow Jackets’ triple-option attack.
No. 17 Baylor vs. West Virginia
The Mountaineers will have to play smart on offense as the Bears have scored more TDs on defense (four) than they have allowed (three).
No. 18 Florida vs. Arkansas
The Gators have won eight in a row against the Razorbacks. The Razorbacks rush for 237 yards per game while the Gators yield just 53.5 yards on the groung.
No. 19 Michigan vs. Minnesota
Wolverines QB Devin Gardner has thrown an interception in nine straight games. The teams have played for the Little Brown Jug since 1909, the oldest trophy game in major college football.
No. 20 Texas Tech at Kansas
Walk-on freshman quarterback Baker Mayfield has recovered from a thigh bruise that caused him to miss the Red Raiders’ last game. The Jayhawks haven’t beaten the Red Raiders since 2001.
No. 21 Oklahoma State vs. Kansas State
The Cowboys are 13-1 in their last 14 home games. The Wildcats are looking to rebound from a poor start to the season after winning the Big 12 last season.
No. 22 Arizona State vs. Notre Dame
After completing 60.7 percent of his passes in his first three games, Irish quarterback Tommy Rees has completed just 39.7 percent over his past two games.
No. 23 Fresno State at Idaho
Bulldogs quarterback Derek Carr ranks second nationally in passing with 361.2 yards per game.
No. 24 Mississippi at Auburn
The Rebels are 2-13 at Jordan-Hare Stadium. Tigers QB Nick Marshall has thrown four picks in two SEC games.