Here are the lineups for Opening Day and a game preview:
RED SOX (97-65 in 2013)
Pitching: LHP Jon Lester (15-8, 3.75 in 2013).
Pitching: RHP Chris Tillman (16-7, 3.71).
Game time: 3:05 p.m.
TV/Radio: NESN, ESPN2 / WEEI.
Red Sox vs. Tillman: Pedroia 8-27, Nava 4-17, Ortiz 1-16, Napoli 4-13, Middlebrooks 0-14, Carp 1-11, Victorino 4-11, Pierzynski 1-10, Bogaerts 0-3, Gomes 0-3, Sizemore 0-3, Ross 0-2.
Orioles vs. Lester: Markakis 16-66, Jones 16-53, Wieters 15-44, Hardy 8-27, Davis 3-24, Cruz 10-22, Reimold 4-12, Pearce 1-8, Weeks 0-4.
Stat of the Day: The Sox are 4-3 on Opening Day the year after winning the World Series with wins in four of their last five games.
Another spring, another shortstop: Xander Bogaerts is the 10th shortstop to start on Opening Day in the last 12 years for the Red Sox. The others: Jose Iglesias, Mike Aviles, Marco Scutaro (twice), Jed Lowrie, Julio Lugo (twice), Alex Gonzalez, Edgar Renteria, Pokey Reese and Nomar Garciaparra.
He owns them (Part 1): Lester is 15-3 with a 2.94 ERA in 25 career starts against the Orioles. He is 8-1, 2.99 in 13 starts at Camden Yards.
He owns them (Part 2): Tillman is 4-2, 2.74 in 11 career starts against the Red Sox. After a rough first appearance against the Sox in his rookie year, the righthander is 4-1, 2.21 in 10 starts since.
For openers: Lester is making his fourth consecutive Opening Day start, the most for the Sox since Pedro Martinez made seven in a row from 1998-2004. Lester was 1-0, 4.15 in his first three Opening Day starts.
Welcome back to baseball: Sizemore will be playing his first regular-season game since Sept. 22, 2011 when he was with the Indians.
In with the new: The Sox have added Burke Badenhop, Edward Mujica, Chris Capuano, A.J. Pierzynski, Jonathan Herrera, and Grady Sizemore to their roster since the World Series. They lost Franklin Morales, Ryan Dempster, Jarrod Saltalamacchia, Stephen Drew, Quintin Berry, and Jacoby Ellsbury.
Red Sox spring training leaders: Mike McCoy 23 games, Jackie Bradley Jr. 57 at-bats, Mike Napoli 9 runs, Will Middlebrooks 18 hits, Xander Bogaerts and A.J. Pierzynski 5 doubles, Bradley, Middlebrooks and Mike Carp with 1 triple, Napoli with five home runs, Napoli with 11 RBIs, Daniel Nava with 10 walks, Bradley with 17 strikeouts, Brock Holt with 3 stolen bases, Nava with three caught stealings, Bryce Brentz in batting average at .360, Deven Marrero in OBP at .462, Brentz in slugging percentage at .720 and Bogaerts in defensive innings with 131.
Clay Buchholz with 3 wins, Allen Webster with 3 losses, Tommy Layne and Brayan Villarreal with 9 appearances, Francisco Cordero with 3 saves, Buchholz and Felix Doubront with 19 innings, Doubront with 30 hits allowed, 15 runs allowed and 15 earned runs; Brandon Workman with 3 home runs allowed, Webster with 9 walks, Doubront with 21 strikeouts, and Cordero with a 0.00 ERA.
Other notes: The Sox are 55-57-1 on Opening Day, 32-40-1 on the road. They are playing on the road for Opening Day for the fourth consecutive season. … The last opening against the Orioles on April 4, 2004, a 7-2 loss at Camden Yards. Sir Sidney Ponson beat Pedro Martinez that day. David Ortiz was 0 for 2 before Ellis Burks pinch-hit for him. Bill Mueller had three hits for the Sox. Manny Ramirez and Johnny Damon drove in runs. … Ortiz is making his 10th Opening Day start for the Sox after missing last season. Pedroia is making his eighth in a row. … The Sox were 8-11 against the Orioles last season and are 13-24 against them the last two seasons.
Song of the Day: “The Boys Are Back” by Dropkick Murphys.