NEW YORK — UConn is back in a familiar place — the No. 1 overall seed in the women’s NCAA basketball Tournament.
But no longer are the Huskies seen as invincible.
Last year, UConn rolled along as the overwhelming favorite before their 111-game winning streak ended with a loss to Mississippi State in the Final Four.
Defending national champion South Carolina and A’ja Wilson await as a possible Elite Eight matchup for UConn in the Albany Regional. The Gamecocks are the No. 2 seed.
‘‘What can you do? You have to beat some pretty good teams. Is it an impossible feat? Obviously not,’’ South Carolina coach Dawn Staley said.
‘‘We saw that last year. If we’re in the position where we have to play them, we’re going to play them. We’re going to give it our best shot and let the chips fall where they may.’’
The Gamecocks lost by 25 at home against UConn on Feb. 1.
Joining the Huskies as top seeds are Notre Dame, Louisville, and Mississippi State.
Mississippi State is a No. 1 seed for the first time in school history.
The Bulldogs won their first 32 games this season before losing to South Carolina in the SEC title game. With most of their players back from last season’s runner-up finish — including Morgan Williams, who hit the game-winner in overtime to knock off UConn — the Bulldogs hope to make another deep NCAA run.
Like the Huskies, the Irish are a No. 1 seed again. Notre Dame has been a top seed the last seven years. This might be one of coach Muffet McGraw’s finest accomplishments as Notre Dame lost four pivotal players to injury, but only three games on the season. Two of those losses came to Louisville.
The Irish are in the Spokane Regional and will open up against Cal State Northridge on Friday. If Notre Dame advances, the Irish would head out west to potentially face No. 2 seed Oregon.
‘‘We've never been in the West bracket. I love playing Friday at 5. That’s awesome,’’ McGraw said.
The Ducks could stay out west and play in Spokane, where coach Kelly Graves spent many years as Gonzaga’s coach.
Ohio State and Texas A&M are the three and four seeds in that region.
Louisville won the Atlantic Coast Conference for the first time this season. The Cardinals open up against Boise State and are one of eight ACC teams in the field. The Southeastern Conference has seven teams in the tournament, while the Pac-12 and the Big Ten have six.
‘‘We’re really excited about the opportunity,’’ Louisville coach Jeff Walz said. ‘‘We’re excited to host the first two at home against two very good basketball teams. If we’re fortunate enough to advance, we get the opportunity to play in Lexington, which would be great for our fans.’’
UConn enters as the lone unbeaten team and will be vying for their 12th national championship. It’s the ninth time that UConn has entered the NCAAs undefeated.
This year’s Final Four is in Columbus, Ohio, and will take place on March 30. The national championship game is on Sunday, April 1.
Florida State and Georgia are the other top seeds in the Huskies’ part of the bracket.
UConn, which has been a No. 1 seed every year since 2007, opens up against No. 16 Saint Francis (Pa.) on Saturday morning. All four top seeds play the opening two rounds at home.
Another in-state team playing in Storrs on Saturday will be ninth-seeded Quinnipiac, which gets Miami in the afternoon game.
As part of the Kansas City Regional, second-seeded Texas will play host to Maine on Saturday at 6 p.m. The Black Bears, who won the America East’s automatic bid, will be playing in their eighth NCAA Tournament and first since 2004.
The Lexington Regional is stacked with former NCAA Tournament winners with Baylor the two-seed, Tennessee the three, and Stanford the four.
While the Lady Vols have been in the NCAA Tournament every year since it began in 1982, Nicholls State, Northern Colorado, Mercer, and Seattle will be making their first appearances.
Oklahoma got in with a 16-14 record — the fewest wins for an at-large team since 2005 — a day after the Oklahoma men got an at-large berth with an 18-13 record and losses in 11 of their final 15 games.
‘‘We spent almost seven hours on that decision of who those last four teams in and first four out were,’’ NCAA women’s basketball committee chair Rhonda Bennett said.
Bennett said Oklahoma’s strength of schedule, which was second best in the country, was a key to its selection.