446 confirmed cases, 14 deaths, and 54,137 vaccinations: See today’s new COVID-19 data from Mass.

A coronavirus shot being preparedCraig F. Walker/Globe Staff

Massachusetts reported 446 new confirmed coronavirus cases Monday, while the seven-day average edged down to 770 from 775 the day before.

The Department of Public Health also reported that the high-stakes campaign to vaccinate people got another 54,137 shots into people’s arms.

The new confirmed coronavirus cases brought the total number in the state during the pandemic to 653,636.

The department also reported 14 new confirmed coronavirus deaths, bringing the state’s total to 17,344.

The state remains in a struggle with the coronavirus more than a year after it arrived. But the state’s vaccination campaign is kicking in, and recent coronavirus numbers have been trending downward.

“I can’t stress enough that these vaccines have proven their mettle here in the Commonwealth. They are safe, they are effective, and they are keeping people healthy, out of the hospital, time and time again. And it shows in our data, not just here in Massachusetts but across the country and around the world,” Governor Charlie Baker said at a Monday news briefing.

The DPH said 18,441 people were estimated to have active cases of the potentially deadly virus, and 427 confirmed coronavirus patients were in the hospital.

The DPH also reported that 23,693 more tests had been conducted for coronavirus. The total number of tests administered climbed to nearly 22 million.

The DPH reported that the seven-day average rate of positive tests, which is calculated from the total number of tests administered, was at 1.26 percent.

The department said the rate would be 2.11 percent if the effect of college testing programs — in which asymptomatic people can be tested repeatedly in an effort to rapidly identify new cases — is factored out.

The number of new coronavirus vaccinations administered in the state brought the total to 6,792,614.

The number of new vaccinations was smaller than on Sunday, when 71,663 were reported. Monday is typically the lowest day of the week for vaccination reports.

The total number of shots administered amounted to 85.5 percent of the 7,941,470 doses shipped to providers in the state so far, the DPH said.

The total shots administered included 3,829,677 first shots and 2,738,737 second shots of the Moderna and Pfizer two-shot vaccines. It also included 224,200 shots of Johnson & Johnson’s one-shot vaccine.

The number of people fully vaccinated — with either two shots of the Moderna or Pfizer vaccines or one shot of the Johnson & Johnson — rose to 2,962,937.