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In its last meeting before a new mayor takes office, the Boston Planning & Development Agency board on Thursday gave the green light to an array of projects around the city, adding up to 4.2 million square feet. The plans range from a massive remake of the old Midtown Hotel on Huntington Avenue to a rethinking of the former site of Doyle’s Cafe in Jamaica Plain to lab space in Allston, Charlestown, and the Fenway.

But the biggest project to win the BPDA’s approval was a one million-square-foot expansion of Massachusetts General Hospital, which aims to put a pair of patient care towers along Cambridge Street on the back side of Beacon Hill.

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As part of the project — which would add beds and facilities to treat cardiac and cancer patients at Mass. General’s main campus — the hospital has agreed to build an entryway to a potential future MBTA Blue Line station and improve sidewalks and bike lanes along the busy stretch of Cambridge Street. Mass. General also pledged financial support to a variety of West End and Beacon Hill civic institutions and to turn over a hospital-owned building for use as affordable housing.

The roughly $2 billion project still needs approval from state health officials, but Thursday’s vote is the key city OK it needs to go forward.

The BPDA board also approved a plan to overhaul the old Midtown Hotel on the edge of the South End and Back Bay. Newton-based National Development, which acquired the site on a long-term lease from the First Church of Christ, Scientist, plans to replace the 159-room hotel with a 10-story, 325-unit apartment building.

Another sizable residential building, this one in the Fenway neighborhood, also won initial approval Thursday. Developer Scape USA is partnering with Boston Children’s Hospital to build a 446-unit building on what is now a parking lot at 819 Beacon St. The building would be mostly rental apartments but would also include 53 units of housing for families of out-of-town patients getting treatment at the hospital. That project will now go to the Zoning Board of Appeal.

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Nearby, at 401 Park Drive, the board approved new owner Alexandria Real Estate Equities’ plan to build a 550,000-square-foot life science office and lab space building on what’s now a low-slung garage, and a storefront occupied by Bed Bath & Beyond. It’s the newest piece of a long-running overhaul of what was previously called Landmark Center, and would include space for a 50,000-square-foot supermarket, part of a deal Star Market has with co-developer Samuels & Associates to sell its nearby store on Boylston Street and move into 401 Park.

Another lab project won approval on Western Avenue in Allston, where developers would replace a string of auto shops and other light industrial buildings on either side of the street with the so-called NEXUS project, a mix of life science and residential space. The four-acre site, just west of Harvard University’s growing Allston campus, would ultimately include 524,000 square feet of lab and life science space, 35 housing units, and street-level retail.

The BPDA also approved a condo building — with a new Doyle’s on the ground floor — on the longtime site of Doyle’s Cafe in Jamaica Plain, another expansion of the Hood Park office complex in Charlestown, and several mid-size residential buildings in Roxbury, and allowed the developers of the long-shuttered Alexandra Hotel on the edge of the South End and Roxbury to convert it to condos instead of a hotel as initially planned before the COVID-19 pandemic.

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The flurry of activity comes as the short-lived Janey administration draws to a close, and many of the BPDA’s senior staff — holdovers from the Walsh administration — remain in place.

The agency scheduled public hearings for several more high-profile projects — including National Development’s re-do of five acres along Dorchester Avenue in South Boston and the addition of lab space to the massive Bulfinch Crossing complex downtown — at its next meeting on Nov. 18. That’s two days after the next mayor — either City Councilor Annissa Essaibi George or City Councilor Michelle Wu — is set to be sworn into office.


Tim Logan can be reached at timothy.logan@globe.com. Follow him on Twitter at @bytimlogan.