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They run health care companies, universities and colleges, financial institutions, nonprofits, construction heavyweights, and more — they’re the women power players of the Bay State. Meet them in the 2021 installment of this list, a joint project of The Commonwealth Institute and the Globe Magazine. Responsible for thousands of employees and billions in revenue, the women featured here drive the Massachusetts economy.

Taken together, the 100 companies on the list represent a total revenue and operating budget of $66.6 billion. (To be precise, $66,634,788,386.)

The Commonwealth Institute's logo for use with the 2021 list of the Top 100 Women-Led Businesses in Massachusetts, in magazine.

How the list was created: For each organization, The Commonwealth Institute, a nonprofit that supports female business leaders, examined revenue or operating budget as well as other variables, including number of full-time employees in the state, workplace and management diversity, and innovative projects. TCI then ranked organizations according to its own formula. This is the 21st year that TCI has created the list and the ninth year that the Globe Magazine has partnered with the group.

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In addition to the list below, some of the Top 100 leaders share key advice for building teams that are prepared for success — even in a crisis. Plus, Globe business columnist Shirley Leung reveals secrets to landing venture capital, NBC10 anchor Latoyia Edwards explains why she’s wearing braids on the morning news now, and a look at how women leaders gained the “empathy advantage” during the pandemic. Explore the entire 2021 Women & Power issue.

*Update: Barbara J. Erickson died in January 2021. Jocelyn Forbush assumed duties of acting president and CEO of The Trustees of Reservations in October 2020.