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Five people were shot, one fatally, in two separate shootings in Roxbury and Mattapan on Wednesday, in a night of violence that swept through Boston’s neighborhoods, police said.

In Roxbury, two people were shot and suffered life-threatening injuries outside an apartment building on Ernst Street, said Officer James Kenneally, a Boston police spokesman.

At midnight, Ernst Street remained closed to traffic and at least 10 police cruisers dotted the road. A neighbor who declined to provide her name said she heard gunshots at about 9 p.m.

“I’m scared,” she said Wednesday night. “It’s not safe here.”

In Mattapan, a man in his 20s was killed when he and two others were shot in the area of Hosmer Street, according to police.

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The three men were at a family gathering when the shots broke out.

One of the men, Toby Gruchy, 20, suffered injuries to his left hip, chest, and elbow, officials said. He was in critical condition at Boston Medical Center.

A second victim, Wesley Perriera, 20, was shot in the right side of his face, left calf, and left thigh, according to officials. He was also in critical condition at Boston Medical.

Police said there is no information on suspects Wednesday night.

Joshua Jackson, 23, lives in the area.

“I thought it was like fireworks,” he said, when he first heard around nine gunshots. “Next thing I know, I see police cars coming out of nowhere.”

The Rev. Wayne S. Daley, of the Boston TenPoint Coalition, denounced the violence at the scene.

“At the end of the day, it’s the families who are losing their kids,” he said. “It’s like I get one, you get one, and it continues to go back and forth. Whatever it is, it needs to just stop.”

Two other shootings occurred in the Boston area late Wednesday into early Thursday. The Associated Press reports a woman was shot and killed early Thursday in a municipal parking lot in Everett, according to police. In Cambridge, a man in his 30s was shot and killed in a car near the Kendall MBTA station on Wednesday night.

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Jan Ransom can be reached at jan.ransom@globe.com. Alexandra Koktsidis can be reached atalexandra.koktsidis@globe.com. Follow her on twitter @akoktsidis. Jacqueline Tempera can be reached at jacqueline.tempera@globe.com.