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    Mass. Pike open in both directions after vehicles removed from crash site in Framingham

    The eastbound lanes of the Massachusetts Turnpike were closed in Framingham for several hours Tuesday following a multiple vehicle crash involving a Massachusetts State Police trooper that left several motorists seriously injured.

    , State Police said six vehicles were involved in the crash, including a box truck, a tractor trailer, two sport utility vehicles, a pickup truck, and an unmarked State Police cruiser.

    The pileup started at 11:12 a.m. when the box truck rear-ended the pickup truck, according to an updated statement from State Police.

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    The pickup caught on fire from the impact and struck the vehicle in front of it, causing a “chain reaction,” police said.

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    “That vehicle was then pushed into another vehicle which was pushed into the trailer,” said State Police.

    One of the sport utility vehicles simultaneously hit the side of the police cruiser, according to police.

    Six of the seven people in the crash were injured, at least three seriously, according to police.

    The 54-year-old man driving the pickup, a Hudson resident, suffered the most incapacitating injuries, and was airlifted to the UMass Memorial Medical Center in Worcester, police said.

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    The driver and passenger of one of the SUVs, a Charlton man and woman, both 66, were taken by ambulance to UMass Memorial, also with incapacitating injuries.

    A 46-year-old Worcester woman driving the other SUV was taken to UMass Medical with non-incapacitating injuries, according to police.

    The box truck driver, a 56-year-old Pepperell man, was taken to the Metrowest Medical Center in Framingham with non-incapacitating injuries.

    The trooper, a 46-year-old man, “suffered potentially incapacitating injuries” and was taken to Beth Israel Hospital, police said.

    The 57-year-old Springfield man driving the tractor trailer was not injured.

    The crash is under investigation.

    Correspondent Alana Leven contributed. John R. Ellement can be reached at ellement@globe.com. Follow him on Twitter @JREbosglobe. Globe correspondent Alana Levene contributed to this report.