An Everett man sustained serious injuries Friday evening after he crashed his moped into the rear of a car on Route 16 in Medford, State Police said.

The 29-year-old operator of the scooter was traveling eastbound in the area of River’s Edge Drive when he struck the 2016 Honda Odyssey around 5:30 p.m., said Lt. Tom Ryan in an interview.

The man was was transported to Massachusetts General Hospital in Boston for treatment of serious injuries, Ryan said.

The driver of the Odyssey, a 45-year-old Somerville woman, was not injured, Ryan said.

State Police are investigating the incident.

Shannon Larson can be reached at shannon.larson@globe.com