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Jeff Hanneman, Slayer guitarist; at 49

From left, Slayer’s Dave Lombardo, Kerry King, Jeff Hanneman, and Tom Araya in a 2009 publicity photo.

Mark Seliger/Associated Press

From left, Slayer’s Dave Lombardo, Kerry King, Jeff Hanneman, and Tom Araya in a 2009 publicity photo.

LOS ANGELES — Slayer guitarist Jeff Hanneman thought he was on the mend after a spider bite followed by an infection. He had been writing songs with the band in anticipation of recording a new album later this year.

But in an unusual chain of events, a representative for the band said the bite may have contributed to Mr. Hanneman’s death more than two years later.

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Mr. Hanneman died Thursday morning of liver failure at a Los Angeles hospital with his wife, Kathy, by his side, according to Slayer spokeswoman Heidi Robinson-Fitzgerald. He was 49.

Family members and doctors were not immediately available to discuss the cause of death.

Robinson-Fitzgerald said Mr. Hanneman had been slowly recovering from necrotizing fasciitis, a flesh-eating disease that nearly cost him his arm. Such an infection can develop from a minor cut or scratch; Robinson-Fitzgerald blamed the spider bite, for which he failed to seek immediate treatment.

Infections by flesh-eating bacteria are rare.

The affliction can destroy muscle, fat, and skin and may require surgery to remove the diseased tissue to save a patient’s life.

Mr. Hanneman had several operations to remove dead and dying tissue from his arm, the band said on its website last year.

The government estimates roughly 750 flesh-eating bacteria cases occur each year, usually caused by a type of strep germ. About 1 in 5 people with the most common kind of flesh-eating strep bacteria die.

People with weakened immune systems can be more at risk.

Flesh-eating bacteria, by itself, doesn’t cause liver failure. But at least one type of strep bacteria can cause streptococcal toxic shock syndrome, which can lead to liver failure.

It is unclear whether an autoposy will be scheduled. No funeral arrangements have been made.

‘‘Jeff Hanneman will always be a metal god,’’ rocker Andrew W.K. posted on Twitter.

Mr. Hanneman cofounded the thrash metal pioneers in Huntington Beach, Calif., in 1982.

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