You can now read 5 articles in a month for free on BostonGlobe.com. Read as much as you want anywhere and anytime for just 99¢.

Transplant reverses sickle cell

A stem-cell transplant reversed sickle cell disease in adults, according to a study that offers a potential cure for the debilitating condition.

Half of those who had the transplant, which involved the patient and a sibling, also were able to stop taking immunosuppressant drugs without experiencing rejection or having the donor cells attack their body, research released Tuesday in the Journal of the American Medical Association showed. People undergoing stem-cell transplants usually must take immunosuppressants for the rest of their lives.

Continue reading below

More than 90,000 people in the United States have sickle cell disease, a genetic disorder found mostly in people of African descent, according to the National Institutes of Health. The condition can cause severe pain, organ damage, and stroke. Study author Matthew Hsieh said it’s too soon to say the researchers have found a cure as patients have been followed only for an average of 3½ years, but he is optimistic.

‘‘They’re sickle-cell free for now,’’ Hsieh, a staff clinician at the National Institute of Diabetes and Digestive and Kidney Diseases and the National Heart, Lung, and Blood Institute in Bethesda, Md., said Tuesday. ‘‘We are cautiously optimistic they are cured.’’

Children with sickle cell can receive a transplant that combines chemotherapy with stem cells, he said. Adults, though, are usually considered too sick for that treatment.

‘‘For a lot of adults, the only option for them is a partial transplant like ours,’’ he said.

The study included 30 patients ages 16 to 65 years who received a transplant that combined their own stem cells and those of a sibling. All the patients had a sibling who was a full match at the white blood cell level, something that occurs about 20 percent of the time, Hsieh said.

Sickle cell disease was reversed in 26 patients, or 87 percent. Fifteen patients discontinued immunosuppressants one year after their transplant and didn’t experience rejection or have the donor cells attack their body, the study showed.

The research also found that following transplant, the patient’s use of narcotics for pain declined as did the rate of hospitalization. Lung function also improved, Hsieh said.

Loading comments...

Wake up with today's top stories.

Want each day's news headlines delivered fresh to your
inbox every morning? Just connect with us
in one of the following ways:
or
Please enter a valid email
BostonGlobe.com will never post anything without asking.
Privacy Policy
Subscriber Log In

You have reached the limit of 5 free articles in a month

Stay informed with unlimited access to Boston’s trusted news source.

  • High-quality journalism from the region’s largest newsroom
  • Convenient access across all of your devices
  • Today’s Headlines daily newsletter
  • Subscriber-only access to exclusive offers, events, contests, eBooks, and more
  • Less than 25¢ a week
Marketing image of BostonGlobe.com
Marketing image of BostonGlobe.com