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    NFL Week 6 preview

    Alex Smith and the 49ers will be looking for revenge against a Giants club that defeated them in last year’s NFC title game.
    Tony Avelar/AP
    Alex Smith and the 49ers will be looking for revenge against a Giants club that defeated them in last year’s NFC title game.

    Indianapolis at New York Jets

    Time: 1 p.m. Line: Jets by 3½.

    Records: Colts 2-2 (2-2 vs. spread), Jets 2-3 (3-2 vs. spread).

    Comments: Proving he still has a sense of humor, Jets coach Rex Ryan announced last week that Raul Ibanez won’t be his starting QB Sunday . . . Indy’s Reggie Wayne leads NFL with 126.5 receiving yards per game . . . Jets QB Mark Sanchez has completed less than 50 percent of his passes in four straight games . . . Colts’ Andrew Luck is second NFLer (Cam Newton) to throw for 300 yards in three of his first four games . . . Indy’s Robert Mathis has at least one sack in seven straight . . . Player to watch: Jets’ Tim Tebow leads all QBs with 711 rushing yards since 2011.


    Key injuries: COLTS: OUT: LB Pat Angerer (foot), RB Donald Brown (knee), LB Robert Mathis (knee), DE Fili Moala (knee), G Joe Reitz (knee), NT Martin Tevaseu (ankle). DOUBTFUL: CB Vontae Davis (ankle). PROBABLE: LB Dwight Freeney (ankle), RB Mewelde Moore (ankle). JETS: DOUBTFUL: RB John Conner (hamstring), DT Kenrick Ellis (knee), WR Clyde Gates (shoulder), DT Sione Po’uha (low back), S Eric Smith (knee). QUESTIONABLE: C Nick Mangold (ankle). PROBABLE: LB Nick Bellore (shoulder), CB Aaron Berry (ribs), CB Antonio Cromartie (shoulder), TE Jeff Cumberland (ribs), TE Dustin Keller (hamstring), S LaRon Landry (heel), LB Calvin Pace (Achilles), QB Mark Sanchez (low back), LB Bart Scott (toe).

    Dallas at Baltimore

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    Time: 1 p.m., Fox. Line: Ravens by 3½.

    Records: Cowboys 2-2 (1-3 vs. spread), Ravens 4-1 (2-3 vs. spread).

    Comments: Stunning but true: Tony Romo has led the Cowboys to two straight wins vs. AFC foes . . . Not-so stunning but just as true: Dallas’s DeMarcus Ware has 30½ sacks in his last 25 games . . . Ravens’ Joe Flacco is 8-0 vs. NFC and Baltimore has won 13 straight regular-season home games . . . Baltimore center Matt Birk poised to play his 200th career game . . . Baltimore ball hawk Ed Reed has three INTs in two games vs. Cowpokes . . . Player to watch: Dallas’s “Smiles” Miles Austin has 57 catches for 980 yards in last nine vs. AFC opponents.

    Key injuries: COWBOYS: OUT: P Brian Moorman (right groin). QUESTIONABLE: C Ryan Cook (hamstring), P Chris Jones (left knee), LB Anthony Spencer (shoulder). PROBABLE: LB Alex Albright (neck), WR Miles Austin (hamstring), CB Morris Claiborne (illness), DT Kenyon Coleman (knee), C Phil Costa (back), S Matt Johnson (hamstring), NT Jay Ratliff (ankle), DE Marcus Spears (knee). RAVENS: PROBABLE: DT Haloti Ngata (shoulder), T Jah Reid (calf).

    New York Giants at San Francisco


    Time: 4:25 p.m., Fox. Line: 49ers by 6½.

    Records: Giants 3-2 (2-2-1 vs. spread), 49ers 4-1 (4-1 vs. spread).

    Comments: Rematch of last season’s NFC Championship game won by the Giants (can’t remember how they did in the Super Bowl, can you?) . . . All-time series is tied, 18-18 (including 4-4 in the postseason) . . . Elite Manning has thrown for at least 200 yards in 24 straight games . . . SF’s Alex Smith has an NFL-high 108.7 passer rating and is fresh off his third career 300-yard game . . . 49ers’ Patrick Willis is one of two players in NFL history with 15-plus sacks and 6 INTs . . . Player to watch: San Fran bruiser Frank Gore has rushed for 7,449 yards since 2006.

    Key injuries: GIANTS: OUT: DT Rocky Bernard (quadriceps), RB Andre Brown (concussion), S Kenny Phillips (knee). QUESTIONABLE: T David Diehl (knee), WR Hakeem Nicks (foot, knee), CB Corey Webster (hand, hamstring). PROBABLE: WR Ramses Barden (concussion), TE Martellus Bennett (knee), LB Chase Blackburn (hip), CB Jayron Hosley (hamstring), LB Keith Rivers (hamstring), S Antrel Rolle (knee). 49ERS: QUESTIONABLE: RB Brandon Jacobs (knee). PROBABLE: P Andy Lee (hand), QB Alex Smith (right finger).

    Green Bay at Houston

    Time: 8:20 p.m., NBC. Line: Texans by 3½.


    Records: Packers 2-3 (1-4 vs. spread), Texans 5-0 (4-1 vs. spread).

    Comments: Pretty important Week 6 game for the suddenly stumbing Packers, who are looking up at the Bears and Vikings . . . Teams meeting for just the third time (1-1) . . . Texans QB Matt Schaub is 9-0 with 13 TDs and 3 INTs in his last nine starts . . . Packers QB Aaron Rodgers has a 113.6 passer rating with 14 TDs and 3 INTs in last five starts vs. AFC . . . Houston’s Andre Johnson is 61 receiving yards shy of 10,000 for his career . . . Player to watch: GB’s Randall “Tex” Cobb has 300 kickoff-return yards, 127 punt-return yards, and 244 receiving yards.

    Key injuries: PACKERS: OUT: WR Greg Jennings (groin), S Sean Richardson (hamstring). QUESTIONABLE: TE Jermichael Finley (shoulder), CB Davon House (shoulder), DT B.J. Raji (ankle), TE D.J. Williams (hamstring). TEXANS: OUT: S Quintin Demps (thumb, forearm). PROBABLE: LB Mister Alexander (Achilles), CB Alan Ball (ankle), G Antoine Caldwell (ankle, foot), NT Shaun Cody (back), RB Justin Forsett (thigh), RB Arian Foster (knee), K Shayne Graham (right calf), WR Lestar Jean (knee), WR Andre Johnson (groin), CB Johnathan Joseph (knee), S Shiloh Keo (neck), LB Jesse Nading (foot), DE Antonio Smith (ankle), G Wade Smith (foot), RB Ben Tate (toe).

    Oakland at Atlanta

    Time: 1 p.m. Line: Falcons by 9.

    Records: Raiders 1-3 (1-3 vs. spread), Falcons 5-0 (4-1 vs. spread).

    Comments: Well, this hardly seems like a fair fight . . . Falcons have never been 5-0 before (seems like Raiders are 1-3 every year) . . . Atlanta’s Roddy White has 93 receptions for 1,343 yards and 11 TDs in last 12 vs. AFC . . . Oakland’s Darren McFadden has rushed for at least 105 yards in three straight vs. NFC . . . Player to watch: Atlanta’s Michael Turner’s teams are 21-1 when he gets 23-plus totes.

    Key injuries: RAIDERS: OUT: T Khalif Barnes (groin), TE Richard Gordon (hamstring), CB Shawntae Spencer (foot). QUESTIONABLE: DT Tommy Kelly (foot). PROBABLE: TE David Ausberry (shoulder), WR Darrius Heyward-Bey (concussion), K Sebastian Janikowski (left groin), RB Taiwan Jones (shoulder), RB Darren McFadden (shoulder), TE Brandon Myers (shoulder), C Alex Parsons (shoulder), DT Richard Seymour (knee). FALCONS: OUT: TE Michael Palmer (shoulder), RB Antone Smith (hamstring). QUESTIONABLE: DT Jonathan Babineaux (groin), LB Stephen Nicholas (ankle). PROBABLE: WR Kevin Cone (knee), WR Drew Davis (knee), DT Peria Jerry (thigh), C Todd McClure (pectoral), S William Moore (hip), G Garrett Reynolds (back), CB Dunta Robinson (shoulder).

    Cincinnati at Cleveland

    Time: 1 p.m. Line: Bengals by 2½.

    Records: Bengals 3-2 (2-2-1 vs. spread), Browns 0-5 (2-2-1 vs. spread).

    Comments: Bengals lead the all-time Buckeye Bowl series, 42-36, and have won 13 of last 16 . . . Cincy QB Andy Dalton is 3-0 with 5 TDs and a 114 passer rating vs. Cleveland . . . Brownies allowed zero sacks last week, snapping a streak of 18 games with at least one sack allowed . . . Bengals have posted an NFL-best 18 sacks . . . Player to watch: Browns rookie QB Brandon Weedon has passed for 1,288 yards.

    Key injuries: BENGALS: QUESTIONABLE: CB Jason Allen (quadriceps), DE Wallace Gilberry (calf), CB Dre Kirkpatrick (knee), LB Dontay Moch (illness). PROBABLE: WR A.J. Green (knee), CB Adam Jones (back), CB Terence Newman (groin), T Andrew Whitworth (knee). BROWNS: OUT: S Tashaun Gipson (knee), WR Mohamed Massaquoi (hamstring), CB Dimitri Patterson (ankle). DOUBTFUL: WR Travis Benjamin (hamstring). QUESTIONABLE: LB Scott Fujita (shoulder, neck), DT Ahtyba Rubin (calf), S Ray Ventrone (hand, calf), S T.J. Ward (hand). PROBABLE: LB D’Qwell Jackson (head), DE Frostee Rucker (shoulder), TE Alex Smith (head).

    St. Louis at Miami

    Time: 1 p.m. Line: Dolphins by 4½.

    Records: Rams 3-2 (4-1 vs. spread), Dolphins 2-3 (3-2 vs. spread).

    Comments: Give yourself a silver star if you knew the Dolphins had the league’s best rush defense (61 yards per game) . . . Rams’ only win in Miami came in 1976 . . . St. Louis rookie Greg Zuerlein is 13 of 13 on field goal attempts, including four of 53 yards or longer . . . Miami’s Dan Carpenter is 0 for 4 on FGs of 47 yards or longer . . . Player to watch: Dolphins’ Cameron Wake has 5½ sacks in his last two games.

    Key injuries: RAMS: OUT: WR Danny Amendola (shoulder), LB Mario Haggan (thigh), T Rodger Saffold (knee). QUESTIONABLE: DT Matthew Conrath (knee), DE William Hayes (back), RB Brit Miller (ankle). PROBABLE: QB Sam Bradford (knee), S Matthew Daniels (thigh), DE Eugene Sims (head). DOLPHINS: OUT: CB Richard Marshall (back), RB Daniel Thomas (concussion). QUESTIONABLE: LB Kevin Burnett (ankle). PROBABLE: RB Reggie Bush (knee), CB Nolan Carroll (Achilles), WR Brian Hartline (quadriceps), S Reshad Jones (back, heel).

    Detroit at Philadelphia

    Time: 1 p.m. Line: Eagles by 3½.

    Records: Lions 1-3 (0-4 vs. spread), Eagles 3-2 (1-3-1 vs. spread).

    Comments: Any other non-fantasy owners know that the Lions’ Matthew Stafford has yet to throw a TD pass to Calvin Johnson this season? . . . Eagles have held foes to just five TDs in 16 red zone trips . . . Detroit has been outscored, 60-31, in the first half . . . Philly TE Brent Celek has 1,062 yards and 6 TDs in last 16 games . . . Player to watch: Detroit’s Ndamukong Suh (looks like a Scrabble rack) has 16½ sacks since 2010.

    Key injuries: LIONS: OUT: DT Corey Williams (knee). QUESTIONABLE: DE Cliff Avril (back), S Louis Delmas (knee), DT Sammie Hill (toe). PROBABLE: LB Travis Lewis (quadriceps), TE Brandon Pettigrew (knee), S Amari Spievey (groin), LB Stephen Tulloch (knee), WR Titus Young (knee). EAGLES: PROBABLE: S Colt Anderson (knee), WR Jason Avant (wrist), RB Bryce Brown (shoulder), WR Riley Cooper (collarbone), C Jon Dorenbos (ankle), T King Dunlap (hamstring), RB Stanley Havili (quadriceps), LB Akeem Jordan (hamstring), LB Mychal Kendricks (ankle), DT Derek Landri (knee), DE Darryl Tapp (foot).

    Kansas City at Tampa Bay

    Time: 1 p.m. Line: Buccaneers by 4.

    Records: Chiefs 1-4 (2-3 vs. spread), Buccaneers 1-3 (3-1 vs. spread).

    Comments: Chiefs QB Brady Quinn expected to make first start since 2009, in place of injured Matt Cassel . . . Series is deadlocked at 5-5 . . . Tampa Bay’s Connor Barth has nailed 25 straight FGs . . . Buccaneers defense allowing just 73.8 yards per game — fourth best in NFL . . . Player to watch: KC’s Jamal Charles averaging 153.6 yards rushing in last three games.

    Key injuries: CHIEFS: OUT: QB Matt Cassel (concussion), DE Glenn Dorsey (calf), RB Peyton Hillis (ankle), WR Devon Wylie (hamstring). QUESTIONABLE: WR Jon Baldwin (hamstring), WR Terrance Copper (calf), RB Cyrus Gray (illness), DE Ropati Pitoitua (elbow). PROBABLE: CB Jalil Brown (hamstring), RB Shaun Draughn (ankle), S Kendrick Lewis (shoulder), G Ryan Lilja (back). BUCCANEERS: QUESTIONABLE: DT Roy Miller (back). PROBABLE: G Carl Nicks (toe), T Jeremy Trueblood (illness), CB Eric Wright (head).

    Buffalo at Arizona

    Time: 4:05 p.m. Line: Cardinals by 4.

    Records: Bills 2-3 (2-3 vs. spread), Cardinals 4-1 (3-2 vs. spread).

    Comments: Cardinals offense has not yet reached 300 total yards in a game (impressive for a 4-1 team) . . . A sort of homecoming for Bills QB and Arizona native Ryan Fitzpatrick, who needs two scoring strikes to become fourth Buffalo signal-caller with 70 . . . Cardinals LB Sam Acho (bless you) has five sacks in last six games . . . Player to watch: Bills’ Stevie Johnson has at least one catch in 37 consecutive games.

    Key injuries: BILLS: OUT: DE Mark Anderson (knee), T Cordy Glenn (ankle), DE Spencer Johnson (ankle), G Kraig Urbik (ankle). QUESTIONABLE: S Jairus Byrd (chest), G Chad Rinehart (calf), DT Kyle Williams (ankle), C Eric Wood (foot). PROBABLE: CB Aaron Williams (hand), DE Mario Williams (wrist). CARDINALS: DOUBTFUL: CB Michael Adams (hamstring), RB Anthony Sherman (knee), CB Greg Toler (hamstring), LB Reggie Walker (head). QUESTIONABLE: DT Darnell Dockett (hamstring), TE Jim Dray (knee), LB Quentin Groves (hamstring), TE Todd Heap (knee), LB Paris Lenon (knee), LB O’Brien Schofield (knee). PROBABLE: RB William Powell (head), QB John Skelton (ankle), G Adam Snyder (elbow), RB LaRod Stephens-Howling (hip).

    Minnesota at Washington

    Time: 4:25 p.m. Line: No line.

    Records: Vikings 4-1 (3-2 vs. spread), Redskins 2-3 (2-3 vs. spread).

    Comments: All-time series is tied at 8-8 . . . Washington QB Robert Griffin III (he’s questionable for this game) leads NFL with 69.1 percent completion percentage while Minnesota QB Christian Ponder is right on his heels at 69.0 percent . . . Redskins LB London Fletcher collected 16 tackles in loss to Vikings last season . . . Washington’s Lorenzo Alexander has NFL-high nine special teams tackles . . . Player to watch: Vikings Jared Allen has 5 sacks, 2 forced fumbles, and 2 recoveries in last three vs. ’Skins.

    Key injuries: VIKINGS: OUT: S Mistral Raymond (ankle). DOUBTFUL: LB Marvin Mitchell (calf). QUESTIONABLE: WR Jerome Simpson (lower back, foot). REDSKINS: OUT: S Brandon Meriweather (knee), DE Doug Worthington (calf). QUESTIONABLE: WR Pierre Garcon (foot), QB Robert Griffin III (head), CB Cedric Griffin (hamstring).

    Denver at San Diego

    Time: Monday, 8:30 p.m., ESPN. Line: Even.

    Records: Broncos 2-3 (2-3 vs. spread), Chargers 3-2 (3-2 vs. spread).

    Comments: Denver’s Peyton Manning is 11-4 on “Monday Night Football” . . . San Diego’s Philip Rivers is 7-3 on “MNF’’ . . . Broncos lead series, 55-48-1 . . . Denver TE Joel Dreessen has a TD catch in three straight games . . . SD’s Antonio Gates is 55 yards shy of passing Ozzie Newsome (7,980) for fourth on all-time list for TEs . . . Manning’s 300-plus yard effort vs. Patriots last week was his 66th, tops all-time . . . Player to watch: Chargers’ Ryan Mathews has rushed for at least 100 yards in all three meetings vs. Denver.

    Key injuries: BRONCOS: DNP: CB Tony Carter (illness), T Ryan Clady (hamstring). FULL: RB Lance Ball (ankle), LB Keith Brooking (concussion), RB Chris Gronkowski (thigh), CB Chris Harris (ankle), G Chris Kuper (forearm), WR Demaryius Thomas (hip), WR Matthew Willis (not injury related). CHARGERS: DNP: T Jared Gaither (groin), K Nate Kaeding (right groin), WR Eddie Royal (hamstring). LIMITED: WR Malcom Floyd (groin). FULL: T Jeromey Clary (foot), RB Ryan Mathews (ankle).

    Jim McBride can be reached at