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Red Sox starter Eduardo Rodriguez left in the sixth inning Saturday’s game against the Toronto Blue Jays with a right ankle sprain after a collision at first base with Blue Jays second baseman Lourdes Gurriel Jr.

X-rays came back negative, and Rodriguez will be evaluated further.

With one out and the bases empty, Gurriel sent a ground ball to the right side of the infield. Sox first baseman Blake Swihart tried to backhand the ball, bobbled it but managed to grab it with his bare hand. With Rodriguez running to cover first, Swihart fired a quick throw that sailed wide.

When Rodriguez turned around, Gurriel was sliding head-first into the bag. Rodriguez tried to jump over Gurriel, but caught his left leg on Gurriel’s helmet. Rodriguez landed awkwardly on his right leg, then tumbled to the grass in foul territory.

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Sox trainers came from the dugout to tend to the Rodriguez. After the left-hander attempted a handful of practice pitches from the mound, Sox manager Alex Cora decided to pull him out of the game.

Rodriguez threw 5⅓ scoreless innings, giving up four hits while striking out five, extending his scoreless innings streak to 19 innings.

Coming into Saturday, Rodriguez was 11-3 with a 3.62 ERA.

Rodriguez had pitched 5<span class="onethird"><span class="web_fractions">⅓</span>
</span> scoreless innings before having to leave the game after this collision.
Rodriguez had pitched 5<span class="onethird"><span class="web_fractions">⅓</span> </span> scoreless innings before having to leave the game after this collision.Barry Chin/Globe Staff
Rodriguez walking with a member of the training staff.
Rodriguez walking with a member of the training staff.Omar Rawlings/Getty Images

Julian Benbow can be reached at jbenbow@globe.com.