New England had last played July 25 in the MLS is Back Tournament at Disney World.
The Union eliminated the Revolution in the MLS is Back tournament.
New England acquired a midfielder and a forward ahead of resuming the 2020 season on Thursday.
It will be the Revolution's first game since a 1-0 loss at the hands of the Union on July 25.
Despite having two teams withdraw because of the coronavirus, pro soccer's return to action was a resounding success.
With six games from Aug. 21-Sept. 12, coach Bruce Arena must get creative with his lineups — especially without the injured Carles Gil.
The MLS played 51 matches in 45 days and by most accounts, it was a rousing success.
The Belmont winner remains undefeated this year with four straight graded stakes victories.